| Digoxin enhances the pressor response to aldosterone administration in conscious sheep. | |
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MedLine Citation:
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PMID: 2721032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. This study examined the hypothesis that inhibition of Na,K ATPase with digoxin would enhance the pressor response to aldosterone infusion in conscious sheep. 2. While intravenous infusion of digoxin (10 micrograms/kg per day for 5 days) had no effect on blood pressure and aldosterone infusion (6 micrograms/kg per day for 5 days) increased blood pressure by 7 mmHg, combined infusion of digoxin and aldosterone increased blood pressure by 17 mmHg. 3. The metabolic effects of the combined digoxin and aldosterone infusion were similar to those for aldosterone alone, suggesting that digoxin did not enhance the mineralocorticoid action of aldosterone. 4. The results of this study suggest that changes in Na influx (aldosterone-dependent) and efflux (digoxin-dependent) are important in the genesis of aldosterone-induced hypertension. |
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Authors:
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C D Spence; J P Coghlan; J A Whitworth; B A Scoggins |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 16 ISSN: 0305-1870 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-07-07 Completed Date: 1989-07-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 211-22 Citation Subset: IM |
Affiliation:
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Howard Florey Institute of Experimental Physiology and Medicine, Parkville, Victoria, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldosterone
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pharmacology* Animals Blood Pressure / drug effects* Digoxin / pharmacology* Drug Synergism Female Hemodynamics / drug effects Sheep |
| Chemical | |
Reg. No./Substance:
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20830-75-5/Digoxin; 52-39-1/Aldosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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