Document Detail


Digitalis-like factor and digoxin-like immunoreactive factor in diabetic women with preeclampsia, transient hypertension of pregnancy, and normotensive pregnancy.
MedLine Citation:
PMID:  7734097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An endogenous sodium pump inhibitor, or digitalis-like factor (DLF), has been postulated to mediate essential hypertension. It may also play a role in preeclampsia. However, studies of this factor in hypertensive pregnancy have not provided consistent findings. Part of this may be due to the absence of subclassification of pregnant women with pregnancy-induced hypertension (PIH) when assessing these parameters. In this study we explored serum DLF and digoxin-like immunoreactive factor (DLIF) in insulin-dependent diabetic (IDDM) women with normotensive pregnancies or PIH, comparing them to each other and to nondiabetic pregnant women. Our results demonstrated that nondiabetic women with preeclampsia (PE, PIH with proteinuria) had significantly increased serum DLF and DLIF compared to normotensive pregnant women (NL BP). Women with transient hypertension of pregnancy (THP, PIH without proteinuria) had intermediate values (DLF. NL BP: 3.3 +/- 0.6, THP: 4.8 +/- 1.1, PE: 7.6 +/- 1.3% inhibition [Na,K]-ATPase, P < .05 ANOVA; DLIF. NL BP: 0.22 +/- 0.02, THP: 0.28 +/- 0.03, PE: 0.35 +/- 0.02 ng digoxin equivalents/mL, P < .05 ANOVA). Pregnant normotensive IDDM women had significantly higher serum DLF and DLIF activity than their nondiabetic counterparts (DLF. non-IDDM NL BP: 3.3 +/- 0.6 v IDDM NL BP: 8.8 +/- 1.2% inhibition [Na,K]-ATPase, P = .0008; DLIF. non-IDDM NL BP: 0.22 +/- 0.02 v IDDM NL BP: 0.31 +/- 0.02 ng digoxin equivalents/mL, P = .005).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S W Graves; K Lincoln; S L Cook; E W Seely
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  8     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Affiliation:
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure
Blood Proteins / metabolism*
Cardenolides
Creatinine / blood
Diabetes Mellitus, Type 1 / blood
Digoxin*
Female
Gestational Age
Humans
Hypertension / blood*,  complications
Pre-Eclampsia / blood*,  complications
Pregnancy
Pregnancy Complications, Cardiovascular / blood*
Pregnancy in Diabetics / blood*
Saponins*
Grant Support
ID/Acronym/Agency:
R01 HD24499/HD/NICHD NIH HHS; RR 02635/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 60-27-5/Creatinine
Comments/Corrections
Comment In:
Am J Hypertens. 1996 May;9(5):516   [PMID:  8735186 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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