Document Detail

Digital vasculitis in patients with cryptogenic fibrosing alveolitis.
MedLine Citation:
PMID:  6722017     Owner:  NLM     Status:  MEDLINE    
Twelve patients are described with features of cryptogenic fibrosing alveolitis (CFA) with associated florid digital vasculitis (DV). Nine patients had features of various 'connective tissue disorders' involving systems other than the lung, but three had no such features. The immunological features of these patients with DV have been compared with a group of 17 patients who had CFA alone ('lone CFA') and in whom the same range of special laboratory tests were being undertaken concurrently. The group with DV had a higher erythrocyte sedimentation rate and a higher serum IgM, but the most interesting immunological distinction was an increased prevalence of antinuclear antibodies with a nucleolar staining pattern. In addition, the group with DV also had a greater prevalence of single stranded DNA antibodies and of smooth muscle autoantibodies. Circulating immune complexes were not detected more frequently in the group with vasculitis. Ten of the 12 patients were initially treated with corticosteroids and neither the vasculitis nor the lungs improved. In eight the incapacitating DV responded to immunosuppressants (four) or penicillamine (four). In three of these eight patients the lungs also improved.
M E Hodson; P L Haslam; S G Spiro; M Turner-Warwick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of diseases of the chest     Volume:  78     ISSN:  0007-0971     ISO Abbreviation:  Br J Dis Chest     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-18     Completed Date:  1984-07-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7511123     Medline TA:  Br J Dis Chest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  140-8     Citation Subset:  IM    
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MeSH Terms
Immunosuppressive Agents / therapeutic use
Middle Aged
Penicillamine / therapeutic use
Prednisolone / therapeutic use
Pulmonary Fibrosis / complications*,  immunology
Skin Diseases / drug therapy,  etiology*,  immunology
Vasculitis / drug therapy,  etiology*,  immunology
Reg. No./Substance:
0/Immunosuppressive Agents; 50-24-8/Prednisolone; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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