Document Detail

Digital plaque imaging evaluation of a stabilized stannous fluoride dentifrice compared with a triclosan/copolymer dentifrice.
MedLine Citation:
PMID:  24640432     Owner:  NLM     Status:  In-Process    
PURPOSE: To compare the relative plaque control efficacy of a marketed 0.454% stabilized stannous fluoride (SnF2) dentifrice relative to a triclosan/copolymer dentifrice using digital plaque imaging analysis (DPIA).
METHODS: This was a randomized, two-treatment, double-blind, parallel group design study that compared SnF2 and triclosan/copolymer dentifrices over a period of 3 weeks. DPIA was used to capture a digital image of the maxillary and mandibular anterior facial surfaces of 12 teeth and to calculate plaque area coverage. Overnight DPIA images were taken at a baseline visit after which subjects were randomly assigned to one of the two treatment groups and were required to brush with their assigned dentifrice according to each manufacturer's instructions. Subjects had DPIA assessments on two separate days at the end of Week 3.
RESULTS: 96 subjects were randomized to treatment. Plaque area data for 47 subjects per treatment group were compared at Week 3 using ANCOVA. The SnF2 group demonstrated a statistically significant reduction in overnight plaque at Week 3 compared to baseline (P= 0.002). The reduction for the triclosan group at Week 3 compared to baseline was not statistically significant (P= 0.24). At Week 3, the SnF2 group demonstrated a 17% lower adjusted mean for overnight plaque relative to the triclosan group with a mean difference that was statistically significant (P< 0.05). The Week 3 adjusted mean change from baseline in overnight plaque for the SnF2 group was 3 times greater versus that of the triclosan group (P< 0.05).
Tao He; Matthew L Barker; Aaron R Biesbrock; Holly Eynon; Jeffery L Milleman; Kimberly R Milleman; Mark S Putt; Ana María Wintergerst
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of dentistry     Volume:  26     ISSN:  0894-8275     ISO Abbreviation:  Am J Dent     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-03-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806701     Medline TA:  Am J Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  D    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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