Document Detail

Digital ischemic loss in systemic sclerosis.
MedLine Citation:
PMID:  20871838     Owner:  NLM     Status:  In-Data-Review    
Digital ischemic loss is a cause of significant morbidity in patients with systemic sclerosis (SSc). Microvascular disease with intimal proliferation and luminal narrowing of small digital arteries, as well as macrovascular disease with narrowing or occlusion of larger digital arteries, contribute to the perfusion defects involved in digital ischemic loss. Immediate clinical evaluation and treatment are mandatory at the onset of critical digital ischemia to prevent digital loss. Hospitalization for medical therapies including intravenous prostacyclin therapy should be considered for all SSc patients who present with critical digital ischemia. Surgical interventions are typically reserved for patients who fail medical therapies and for those with late stage, necrotic tissue. This paper summarizes the current knowledge regarding the risk factors, pathogenesis, evaluation, and treatment of digital ischemic loss in SSc.
Umaima Marvi; Lorinda Chung
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Publication Detail:
Type:  Journal Article     Date:  2010-08-24
Journal Detail:
Title:  International journal of rheumatology     Volume:  2010     ISSN:  1687-9279     ISO Abbreviation:  Int J Rheumatol     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101519204     Medline TA:  Int J Rheumatol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA.
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