| Digital ischemic loss in systemic sclerosis. | |
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MedLine Citation:
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PMID: 20871838 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Digital ischemic loss is a cause of significant morbidity in patients with systemic sclerosis (SSc). Microvascular disease with intimal proliferation and luminal narrowing of small digital arteries, as well as macrovascular disease with narrowing or occlusion of larger digital arteries, contribute to the perfusion defects involved in digital ischemic loss. Immediate clinical evaluation and treatment are mandatory at the onset of critical digital ischemia to prevent digital loss. Hospitalization for medical therapies including intravenous prostacyclin therapy should be considered for all SSc patients who present with critical digital ischemia. Surgical interventions are typically reserved for patients who fail medical therapies and for those with late stage, necrotic tissue. This paper summarizes the current knowledge regarding the risk factors, pathogenesis, evaluation, and treatment of digital ischemic loss in SSc. |
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Authors:
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Umaima Marvi; Lorinda Chung |
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Publication Detail:
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Type: Journal Article Date: 2010-08-24 |
Journal Detail:
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Title: International journal of rheumatology Volume: 2010 ISSN: 1687-9279 ISO Abbreviation: Int J Rheumatol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101519204 Medline TA: Int J Rheumatol Country: Egypt |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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