Document Detail


Digital intravenous ventriculography: analysis and validation of wall thickness changes during ischemia and inotropic stimulation in dogs.
MedLine Citation:
PMID:  7124647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess regional ventricular wall thickening, we studied 8 open-chest dogs using digital intravenous ventriculography at a control stage, after subtotal and total coronary occlusion, and then after isoproterenol administration. In 3 dogs, 2 pairs of myocardial thickness crystals were implanted. Correlations of measures of wall thickness and percentage of wall thickening with crystal measures were excellent at the base (r greater than or equal to 0.97) and near the apex (r greater than or equal to 0.97). Four areas of the inferoapical wall muscle were measured: the base, mid-wall, distal wall, and apex. Four chamber dimensions were also examined: the long axis, base decreased with ischemia. At completion occlusion, it was -24.6 +/- 6% at the base, -27.3 +/- 5% at the mid-wall, -27.1 +/- 5% at the distal wall, and -24.7 +/- 5% at the apex. Percent thickening decreased with occlusion, although greater at the base and mid-wall than at the distal wall and apex. With isoproterenol, end-diastolic thickness increased only at the apex, with little change at the base, distal wall, and mid-wall. Percent thickening increased. In general, ischemia produced increases in end-diastolic hemichords with little change in the long axis. Isoproterenol reduced the hemichords, although the long axis did not change. We conclude the digital intravenous ventriculograms can be used to assess changes in wall thickness with high degrees of accuracy. Asymmetric thickening occurred at rest, with ischemia and with inotropic stimulation, being greatest at the apex and least at the base.
Authors:
R A Slutsky; K H Gerber; C B Higgins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  50     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  874-80     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Occlusive Diseases / etiology
Coronary Circulation / drug effects
Coronary Disease / diagnosis,  radiography*
Dogs
Heart Ventricles / physiopathology,  radiography*
Hemodynamics / drug effects
Isoproterenol / pharmacology
Myocardial Contraction / drug effects*
Systole / drug effects
Ultrasonography*
Grant Support
ID/Acronym/Agency:
1K04HL2001/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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