Document Detail


Digging deeper into obesity.
MedLine Citation:
PMID:  21633174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The growing problem of obesity is associated with multiple morbidities, including increased risk of diabetes, hypertension, heart disease, sleep apnea, and cancer. Obesity promotes disability, decreases productivity, and shortens life span. Although much attention has been focused on diet and exercise, these strategies alone are not effective in preventing obesity and maintaining weight loss. Moreover, the development of pharmacological approaches for obesity treatment has been dogged by poor efficacy and serious side effects. The biology of obesity is very complex, and mechanisms linking obesity to various diseases are poorly understood. This issue of the JCI highlights important concepts in our understanding of the pathogenesis of obesity and its complications.
Authors:
Rexford S Ahima
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Publication Detail:
Type:  Introductory Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-06-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  121     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-02     Completed Date:  2011-08-17     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2076-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, and the Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. ahima@mail.med.upenn.edu
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MeSH Terms
Descriptor/Qualifier:
Humans
Morbidity / trends
Obesity* / epidemiology,  etiology,  immunology,  metabolism,  physiopathology
Grant Support
ID/Acronym/Agency:
P01-DK049210/DK/NIDDK NIH HHS; P30-DK19525/DK/NIDDK NIH HHS; R01-DK062348/DK/NIDDK NIH HHS
Comments/Corrections

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