| Difluoromethylornithine: the proof is in the polyamines. | |
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MedLine Citation:
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PMID: 23221207 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In this issue (beginning on page 1368), Kreul and colleagues report a retrospective review of long-term efficacy and toxicity for subjects participating in a phase III study of difluoromethylornithine (DFMO) for prevention of nonmelanoma skin cancer (NMSC). They conclude that those treated with DFMO had a nonsignificant, persistent decrease in NMSC after completion of treatment and that treatment with DFMO did not result in late toxicity after the discontinuation of treatment. We review the data on DFMO as a chemopreventive agent for skin and other cancers, discuss the necessary qualities of a cancer chemopreventive agent, and reflect on the requirements for a well-conducted cancer chemoprevention study, including the rationale for long-term follow-up in cancer prevention studies. Cancer Prev Res; 5(12); 1341-4. ©2012 AACR. |
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Authors:
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Joanne M Jeter; David S Alberts |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer prevention research (Philadelphia, Pa.) Volume: 5 ISSN: 1940-6215 ISO Abbreviation: Cancer Prev Res (Phila) Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101479409 Medline TA: Cancer Prev Res (Phila) Country: United States |
Other Details:
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Languages: eng Pagination: 1341-4 Citation Subset: IM |
Affiliation:
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The University of Arizona Cancer Center, 3838 N. Campbell Avenue, Tucson, AZ 85719. dalberts@azcc.arizona.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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