Document Detail


Difluoromethylornithine: the proof is in the polyamines.
MedLine Citation:
PMID:  23221207     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this issue (beginning on page 1368), Kreul and colleagues report a retrospective review of long-term efficacy and toxicity for subjects participating in a phase III study of difluoromethylornithine (DFMO) for prevention of nonmelanoma skin cancer (NMSC). They conclude that those treated with DFMO had a nonsignificant, persistent decrease in NMSC after completion of treatment and that treatment with DFMO did not result in late toxicity after the discontinuation of treatment. We review the data on DFMO as a chemopreventive agent for skin and other cancers, discuss the necessary qualities of a cancer chemopreventive agent, and reflect on the requirements for a well-conducted cancer chemoprevention study, including the rationale for long-term follow-up in cancer prevention studies.
Authors:
Joanne M Jeter; David S Alberts
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Cancer prevention research (Philadelphia, Pa.)     Volume:  5     ISSN:  1940-6215     ISO Abbreviation:  Cancer Prev Res (Phila)     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-23     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  101479409     Medline TA:  Cancer Prev Res (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1341-4     Citation Subset:  IM    
Copyright Information:
©2012 AACR
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MeSH Terms
Descriptor/Qualifier:
Eflornithine / pharmacology*
Female
Humans
Male
Skin Neoplasms / prevention & control*
Grant Support
ID/Acronym/Agency:
P01 CA027502/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
ZQN1G5V6SR/Eflornithine
Comments/Corrections
Comment On:
Cancer Prev Res (Phila). 2012 Dec;5(12):1368-74   [PMID:  23060038 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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