Document Detail


Diflucortolone valerate (Nerisona): a comparative vasoconstriction test in artificially induced hyperemia of the skin.
MedLine Citation:
PMID:  7459929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 20 healthy volunteers of both sexes the vasoconstrictive activity of diflucortolone valerate in two of its commercially available formulations (water-in-oil emulsion and pure fat base) was compared with that of four other substances: fluocinonide; betamethasone-17,21-dipropionate; hydrocortisone-17-butyrate; and clobetasol-17-propionate in corresponding galenical formulations. The visual assessment of vasoconstrictive activity after 10 hours revealed a statistically significant superiority of diflucortolone valerate in its fat base over the corresponding galenical formulations of fluocinonide, clobetasol-17-propionate, and hydrocortisone-17-butyrate. Diflucortolone valerate in a water-in-oil emulsion was statistically better after eight hours than the cream formulations of fluocinonide; clobetasol-17-propionate, and betamethasone-17,21-dipropionate.
Authors:
R Reckers; H Wendt
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  3     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1980  
Date Detail:
Created Date:  1981-04-24     Completed Date:  1981-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  190-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Anti-Inflammatory Agents / pharmacology
Diflucortolone / analogs & derivatives*,  pharmacology
Female
Fluocortolone / analogs & derivatives*
Glucocorticoids
Humans
Male
Regional Blood Flow / drug effects
Skin / blood supply*
Skin Tests
Vasoconstriction / drug effects*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 152-97-6/Fluocortolone; 2607-06-9/Diflucortolone; 59198-70-8/diflucortolone valerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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