| Diffusion-weighted magnetic resonance imaging characteristics of hemorrhagic transformation in experimental embolic stroke. | |
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MedLine Citation:
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PMID: 9344005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Diffusion-weighted magnetic resonance imaging (MRI) can detect ischemia within minutes of onset, but its ability to reliably detect hyperacute cerebral hemorrhage is unknown. The present study characterized diffusion-weighted, T2-weighted, and contrast-enhanced T1-weighted MRI appearances of hemorrhagic transformation within 5 hours of onset in experimental embolic stroke. Apparent diffusion coefficients and MRI signal characteristics were noted within corresponding regions of hemorrhage observed on gross pathology. Apparent diffusion coefficients were significantly increased within hemorrhagic lesions, but were still within the expected range for bland ischemia. The appearance of the hemorrhagic lesions on diffusion-weighted MRI was also very heterogeneous and not very useful for clinical screening. Other MRI modalities should be investigated, but computed tomography remains the only widely available clinical method of reliably detecting cerebral hemorrhage. |
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Authors:
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M A Yenari; C Beaulieu; G K Steinberg; M E Moseley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 7 ISSN: 1051-2284 ISO Abbreviation: J Neuroimaging Publication Date: 1997 Oct |
Date Detail:
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Created Date: 1997-12-02 Completed Date: 1997-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-31 Citation Subset: IM |
Affiliation:
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Department of Neurology, Stanford Stroke Center, Stanford University Medical Center, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Brain Ischemia / diagnosis, drug therapy, pathology Cerebral Hemorrhage / diagnosis*, pathology, radiography Cerebrovascular Disorders / diagnosis*, pathology, radiography Contrast Media Diffusion Fibrinolytic Agents / therapeutic use Image Enhancement Intracranial Embolism and Thrombosis / diagnosis*, drug therapy, pathology, radiography Magnetic Resonance Imaging / methods* Male Rabbits Random Allocation Reproducibility of Results Thrombolytic Therapy Time Factors Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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