Document Detail

Diffusion-weighted magnetic resonance imaging characteristics of hemorrhagic transformation in experimental embolic stroke.
MedLine Citation:
PMID:  9344005     Owner:  NLM     Status:  MEDLINE    
Diffusion-weighted magnetic resonance imaging (MRI) can detect ischemia within minutes of onset, but its ability to reliably detect hyperacute cerebral hemorrhage is unknown. The present study characterized diffusion-weighted, T2-weighted, and contrast-enhanced T1-weighted MRI appearances of hemorrhagic transformation within 5 hours of onset in experimental embolic stroke. Apparent diffusion coefficients and MRI signal characteristics were noted within corresponding regions of hemorrhage observed on gross pathology. Apparent diffusion coefficients were significantly increased within hemorrhagic lesions, but were still within the expected range for bland ischemia. The appearance of the hemorrhagic lesions on diffusion-weighted MRI was also very heterogeneous and not very useful for clinical screening. Other MRI modalities should be investigated, but computed tomography remains the only widely available clinical method of reliably detecting cerebral hemorrhage.
M A Yenari; C Beaulieu; G K Steinberg; M E Moseley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimaging : official journal of the American Society of Neuroimaging     Volume:  7     ISSN:  1051-2284     ISO Abbreviation:  J Neuroimaging     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-12-02     Completed Date:  1997-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102705     Medline TA:  J Neuroimaging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-31     Citation Subset:  IM    
Department of Neurology, Stanford Stroke Center, Stanford University Medical Center, CA, USA.
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MeSH Terms
Analysis of Variance
Brain Ischemia / diagnosis,  drug therapy,  pathology
Cerebral Hemorrhage / diagnosis*,  pathology,  radiography
Cerebrovascular Disorders / diagnosis*,  pathology,  radiography
Contrast Media
Fibrinolytic Agents / therapeutic use
Image Enhancement
Intracranial Embolism and Thrombosis / diagnosis*,  drug therapy,  pathology,  radiography
Magnetic Resonance Imaging / methods*
Random Allocation
Reproducibility of Results
Thrombolytic Therapy
Time Factors
Tomography, X-Ray Computed
Reg. No./Substance:
0/Contrast Media; 0/Fibrinolytic Agents

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