Document Detail

Diffusion-weighted imaging of the liver: optimizing b value for the detection and characterization of benign and malignant hepatic lesions.
MedLine Citation:
PMID:  18777553     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine the optimal b values required for diffusion-weighted (DW) imaging of the liver in the detection and characterization of benign and malignant hepatic lesions. MATERIALS AND METHODS: MR images obtained in 76 patients including 28 malignant hepatic lesions (21 hepatocellular carcinomas and 7 metastases) and 27 benign lesions (12 hemangiomas and 15 cysts) were reviewed. DW-echo planner images (EPIs; b values with 100, 200, 400, and 800 s/mm2) were reviewed solely first, and then with T2-weighted EPIs (b=0 s/mm2). RESULTS: Sensitivity for malignant lesions (74%) was highest on DW-EPIs with b value of 100 s/mm2 and T2-weighted EPIs combined (P<0.05), and sensitivity for benign lesions (87%) was highest on DW-EPIs with b value of 800 s/mm2 and T2-weighted EPIs (P<0.05). Specificities were comparably high for all sequences. The Az values for malignant lesions were 0.94, 0.90, 0.87, and 0.89, and those for benign lesions were 0.91, 0.89, 0.87, and 0.94 on DW-EPIs with b values of 100, 200, 400, and 800 and T2-weighted EPIs combined, respectively. Hepatic cysts were clearly distinguished with the cutoff ADC value of 2.5x10(-3) mm2/s using a b value of 400 s/mm2 or greater. CONCLUSION: DW-EPIs with middle b values were not required in the detection and characterization of benign and malignant hepatic lesions.
Satoshi Goshima; Masayuki Kanematsu; Hiroshi Kondo; Ryujiro Yokoyama; Kimihiro Kajita; Yusuke Tsuge; Haruo Watanabe; Yoshimune Shiratori; Minoru Onozuka; Noriyuki Moriyama
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  28     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  691-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2008 Wiley-Liss, Inc.
Department of Radiology, Gifu University School of Medicine, Gifu University Hospital, Gifu, Japan.
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MeSH Terms
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging / methods*
Image Enhancement / methods*
Image Interpretation, Computer-Assisted / methods*
Liver Neoplasms / diagnosis*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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