Document Detail

Diffusion-weighted imaging for the follow-up of patients after matrix-associated autologous chondrocyte transplantation.
MedLine Citation:
PMID:  19181469     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the use of diffusion-weighted imaging (DWI) for the assessment of cartilage maturation in patients after matrix-associated autologous chondrocyte transplantation (MACT). MATERIALS AND METHODS: Fifteen patients after MACT were examined by 3.0-T magnetic-resonance-tomography; the examination was up to 13 month after surgery in group 1, and later than 13 month after surgery in group 2. Both groups had a follow-up one-year later. DWI was acquired using a steady-state gradient-echo sequence. Mean values of the diffusion quotients of regions of interest within cartilage repair tissue and of reference regions were assessed. Each region-of-interest was subdivided into a deep, and a superficial area. RESULTS: Mean diffusion quotients of cartilage repair tissues were 1.44 (baseline), and 1.44 (follow-up). Mean diffusion quotients of reference tissues were 1.29 (baseline) and 1.28 (follow-up). At the follow-up diffusion quotients of cartilage repair tissue were significantly higher than those of reference cartilage. In group 1 the diffusion quotients were significantly lower at the follow-up (1.45 versus 1.65); in group 2 no statistically significant differences between follow-up (1.39) and baseline (1.41) were found. Reference cartilages and cartilage repair tissues of group 2 showed a decrease of diffusion quotients from the deep to the superficial area being stable at the follow-up. In group 1 initially a significant increase (1.49 versus 1.78) of the diffusion quotients from deep to superficial area of the cartilage repair tissue was found changing into a decrease (1.65 versus 1.52) at the follow-up. CONCLUSIONS: DWI detected changes of diffusion within cartilage repair tissue that may reflect cartilage maturation. Changes in diffusity occurred up to two years after surgery and were stable later. Zonal variations within cartilage could be measured.
Klaus M Friedrich; Tallal C Mamisch; Christina Plank; Georg Langs; Stefan Marlovits; Erich Salomonowitz; Siegfried Trattnig; Götz Welsch
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Publication Detail:
Type:  Journal Article     Date:  2009-01-31
Journal Detail:
Title:  European journal of radiology     Volume:  73     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-22     Completed Date:  2010-07-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  622-8     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Medical University Vienna, Department of Radiology, MR Center of Excellence, Vienna, Austria.
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MeSH Terms
Analysis of Variance
Cartilage, Articular / pathology*
Chondrocytes / transplantation*
Diffusion Magnetic Resonance Imaging / methods*
Follow-Up Studies
Knee Joint / pathology,  surgery*
Middle Aged
Transplantation, Autologous
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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