| Diffusion-weighted imaging of cerebral white matter and the cerebellum following preterm birth. | |
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MedLine Citation:
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PMID: 20132141 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to determine if apparent diffusion coefficients (ADCs) generated with diffusion-weighted imaging of cerebral white matter and the cerebellum are affected by white matter damage. METHOD: Seventy-two preterm infants (32 males, 40 females; mean gestational age at birth 30.3 wks, SD 3.0 wks; mean birthweight 1458g, SD 534g) underwent magnetic resonance imaging of the brain around term-equivalent age and were categorized into three groups: normal, overt abnormality, and diffuse excessive high signal intensity (DEHSI). ADC values were calculated from cerebral white matter, cerebellar hemispheres, and cerebellar midline, and were compared between groups. Regression analysis identified clinical parameters correlated with ADC values. RESULTS: Imaging was normal in 27 infants, and revealed overt abnormalities in 14 and DEHSI in 31. ADC values did not differ between groups. ADC values from cerebral white matter were negatively correlated with the number of episodes of postnatal sepsis (p=0.002). ADC values from cerebellar hemispheres (p=0.007) and cerebellar midline (p=0.036) correlated with gestational age at birth. INTERPRETATION: ADC values from white matter are not altered in preterm infants with DEHSI but are negatively correlated with the number of episodes of postnatal sepsis. ADC values in the cerebellum are not altered by white matter damage, but are affected by preterm birth itself. |
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Authors:
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Anthony R Hart; Elspeth H Whitby; Simon J Clark; Martyn N J Paley; Michael F Smith |
Publication Detail:
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Type: Journal Article Date: 2010-01-28 |
Journal Detail:
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Title: Developmental medicine and child neurology Volume: 52 ISSN: 1469-8749 ISO Abbreviation: Dev Med Child Neurol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-07-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0006761 Medline TA: Dev Med Child Neurol Country: England |
Other Details:
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Languages: eng Pagination: 652-9 Citation Subset: IM |
Affiliation:
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Department of Neonatology, Sheffield Teaching Hospital NHS Foundation Trust, Tree Root Walk, Sheffield, UK. t.hart@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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abnormalities,
pathology* Cerebellum / abnormalities, pathology Diffusion Magnetic Resonance Imaging / methods* Female Humans Infant, Newborn Infant, Premature* Male Nerve Fibers, Myelinated / pathology Premature Birth Regression Analysis Sepsis / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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