Document Detail

Diffusion-weighted imaging of the brain in preterm infants with focal and diffuse white matter abnormality.
MedLine Citation:
PMID:  12837859     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The most common finding on magnetic resonance imaging (MRI) of the brain in preterm infants at term-equivalent age is diffuse excessive high signal intensity (DEHSI) in the white matter. It is unclear whether DEHSI represents a biological abnormality. This study used diffusion-weighted imaging (DWI) to compare apparent diffusion coefficient (ADC) values in DEHSI with infants with normal imaging and those with overt brain damage to determine whether DEHSI shows the diffusion characteristics of normal or abnormal tissue. METHODS: MRI, using conventional and diffusion-weighted imaging (DWI), was performed in 50 preterm infants at term-equivalent age using a 1.5 Tesla MR scanner. The infants were divided into 3 groups on the basis of their MRI results: 1) normal white matter, 2) DEHSI, or 3) overt white matter pathology. ADC values were measured in the frontal, central, and posterior white matter at the level of the centrum semiovale. ADC values in the 3 groups of preterm infants were compared using a 1-way analysis of variance with a Bonferroni test for multiple comparisons. RESULTS: ADC values were significantly higher in infants with DEHSI and infants with overt white matter pathology than in infants with normal white matter. There was no significant difference between ADC values in infants with DEHSI and those with overt white matter pathology. CONCLUSIONS: This study provides objective evidence that DEHSI represents diffuse white matter abnormality.
Serena J Counsell; Joanna M Allsop; Michael C Harrison; David J Larkman; Nigel L Kennea; Olga Kapellou; Frances M Cowan; Joseph V Hajnal; A David Edwards; Mary A Rutherford
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatrics     Volume:  112     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  AIM; IM    
Robert Steiner Magnetic Resonance Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, London, United Kingdom.
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MeSH Terms
Body Water / metabolism
Brain / pathology*
Infant, Newborn
Infant, Premature*
Leukomalacia, Periventricular / metabolism,  pathology*
Magnetic Resonance Imaging / methods*
Comment In:
Pediatrics. 2003 Jul;112(1 Pt 1):176-80   [PMID:  12837883 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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