Document Detail


Diffusion-weighted Magnetic Resonance Imaging for the Staging of Liver Fibrosis.
MedLine Citation:
PMID:  21716125     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Diffusion-weighted magnetic resonance (MR) imaging (DWI) has been suggested for staging liver fibrosis. The aim of this study was to evaluate the diagnostic accuracy of DWI for the noninvasive assessment of hepatic fibrosis. METHODS: We retrospectively compared DWI from clinically acquired MR scans with histologic methods. Liver biopsy specimens were staged F0-F4 in accordance with the METAVIR score. Hepatic steatosis was classified on a 5-point scale. Hepatic iron was graded on a 3-point scale. Liver inflammation was scored according to the modified hepatic activity index. Nonparametric methods, linear regression models, and receiver operating characteristic analyses were used to determine diagnostic accuracy and apparent diffusion coefficient (ADC) cutoff values. RESULTS: Liver ADC values were inversely correlated with fibrosis stage: P=-0.54 (P<0.0001). Although there was substantial overlap in the ADC distributions, the differences in ADC values by METAVIR stages F0 versus (vs.) F1-4, F0-1 versus F>1, F0-2 versus F3-4 and F0-3 versus F4 were all significant. For prediction of fibrosis stage 1, stage 2, stage 3, and stage 4 area under the receiver operating characteristic curve of 0.79, 0.77, 0.77, and 0.79 were obtained, respectively. Inflammation also correlated significantly with ADC values (P=-0.23, P=0.03), but iron content (P=0.17) or steatosis (P=0.63) did not correlate with ADC measurements. CONCLUSIONS: Liver ADC can be used to predict liver fibrosis with acceptable diagnostic accuracy. DWI should be included in further prospective studies to validate a comprehensive MR imaging protocol for the noninvasive assessment of hepatic fibrosis.
Authors:
Susanne Bonekamp; Michael S Torbenson; Ihab R Kamel
Related Documents :
21996645 - Metronidazole-induced central nervous system toxicity: a systematic review.
22203445 - Automated quantitative rb-82 3d pet/ct myocardial perfusion imaging: normal limits and ...
25457575 - Two cases of sclerosing angiomatoid nodular transformation of the spleen with gradual g...
22271005 - Contrast-enhanced ultrasonography (ceus) vs. mri of the small bowel in the evaluation o...
10576725 - Mri appearance of cervical incompetence in a pregnant patient.
9186215 - Radial displacement of the medial meniscus and fairbank's signs.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-28
Journal Detail:
Title:  Journal of clinical gastroenterology     Volume:  -     ISSN:  1539-2031     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7910017     Medline TA:  J Clin Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions †Department of Pathology, Johns Hopkins University School of Medicine ‡Department of Radiology, MRI Division, Johns Hopkins University, Baltimore, MD.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How patients view probiotics: findings from a multicenter study of patients with inflammatory bowel ...
Next Document:  Central Blood Pressure, Arterial Waveform Analysis, and Vascular Risk Factors in Glaucoma.