| Diffusion-weighted MR imaging of kidneys in patients with chronic kidney disease: initial study. | |
| | |
MedLine Citation:
|
PMID: 19789876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To prospectively evaluate the feasibility of diffusion-weighted (DW) magnetic resonance (MR) imaging in the assessment of renal function in patients with chronic kidney disease (CKD). METHODS: Seventy-two healthy volunteers and 43 patients underwent coronal echo-planar DW MR imaging of the kidneys with a single breath-hold time of 16 s. The patients were grouped according to five stages as indicated by the K/DOQI CKD (kidney disease outcome quality initiative). The apparent diffusion coefficient (ADC) value of the kidneys was calculated with high b values (b = 500 s/mm(2)). The ADC values were compared between patients and healthy volunteers, and among different stages. For statistical analysis, Student's t tests, ANOVA, Pearson's correlation tests, and Spearman's correlation tests were used. RESULTS: No difference between the cortex and medulla could be observed on DW images of all volunteers. Patients with CKD had significantly lower renal ADC (t = -4.383, P = 0.000) than volunteers. The ADC values of kidneys were significantly lower than normal at most stages of CKD, except CKD1. There was a negative correlation between the ADCs and serum creatinine (sCr) level (P = 0.000) amongst the patients. CONCLUSION: Diffusion-weighted MR imaging is feasible in the assessment of renal function, especially in the detection of early stage renal failure of CKD. |
| | |
Authors:
|
Xueqin Xu; Wenqiang Fang; Huawei Ling; Weimin Chai; Kemin Chen |
Related Documents
:
|
15839846 - Diffusion- and perfusion-weighted mr imaging in persistent migrainous visual disturbances. 18324406 - Diffusion-weighted imaging in patients with progressive multifocal leukoencephalopathy. 15747136 - Diffusion-weighted imaging-guided resection of intracerebral lesions involving the opti... 15548506 - Tissue at risk concept for endovascular treatment of severe vasospasm after aneurysmal ... 9751926 - Volumetric measurements of bone mineral density of the lumbar spine: comparison of thre... 9084076 - Evaluation of hepatic perfusion disorders with double-phase spiral ct. |
Publication Detail:
|
Type: Journal Article Date: 2009-09-30 |
Journal Detail:
|
Title: European radiology Volume: 20 ISSN: 1432-1084 ISO Abbreviation: Eur Radiol Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-03-10 Completed Date: 2010-06-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9114774 Medline TA: Eur Radiol Country: Germany |
Other Details:
|
Languages: eng Pagination: 978-83 Citation Subset: IM |
Affiliation:
|
Department of Radiology, Ruijin Hospital Shanghai Jiaotong University School of Medicine, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Algorithms* Diffusion Magnetic Resonance Imaging / methods* Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Kidney / pathology* Kidney Failure, Chronic / diagnosis* Male Middle Aged Pilot Projects Reproducibility of Results Sensitivity and Specificity Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Systemic lupus erythematosus associated with vasculitic syndrome (Takayasu's arteritis).
Next Document: Development and validation of a low dose simulator for computed tomography.