| Diffusion-weighted MR imaging and apparent diffusion coefficient of the normal fetal lung: preliminary experience. | |
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MedLine Citation:
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PMID: 18567059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess if a correlation is present between apparent diffusion coefficient (ADC) values and normal lung maturation during gestation to define potential reference values as indicators of the lung development. METHODS: Our study included 50 pregnant women (gestational age, GA: 18-36 weeks), with normal fetal development of lungs assessed by a previous obstetric ultrasound (US), and then confirmed by our magnetic resonance (MR) examination. We used T2-weighted sequences, diffusion-weighted imaging sequences (DWI) and ADC maps for studying pulmonary tissue. In all cases the resulting ADC values were related to GA using Pearson correlation. RESULTS: ADC values ranged from 1,2 microm(2)/ms at 18 weeks' gestation to 3,9 microm(2)/ms at 36 weeks' gestation with a mean value, regardless for the gestational age, of 2, 352 +/- 0,623106 microm(2)/ms. We found a significant correlation between ADC and gestational age (Pearson correlation = 0,816). CONCLUSION: The ADC values correlate with gestational age since alveolar fluid secretion and angiogenesis increase gradually. Therefore, ADC can be considered as a new parameter for studying lung maturity. |
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Authors:
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Lucia Manganaro; Anna Perrone; Simona Sassi; Francesca Fierro; Sara Savelli; Marco Di Maurizio; Alessandra Tomei; Antonella Francioso; Laura La Barbera; Antonella Giancotti; Laura Ballesio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 28 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-31 Completed Date: 2008-10-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 745-8 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Radiological Sciences, Sapienza University of Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Diffusion Magnetic Resonance Imaging* Female Gestational Age Humans Lung / embryology* Pregnancy Reference Values |
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