| Diffusion tensor imaging and white matter tractography in patients with brainstem lesions. | |
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MedLine Citation:
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PMID: 17712509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Diffusion tensor imaging (DTI) and white matter tractography (WMT) are promising techniques for estimating the course, extent, and connectivity patterns of the white matter (WM) structures in the human brain. In this study, we investigated the ability of DTI and WMT to visualize white matter tract involvement for the preoperative surgical planning and postoperative assessment of brainstem lesions. METHODS: Preoperative and postoperative DTI data (echo-planar, 1.5T) were retrospectively analyzed in 10 patients with brainstem lesions (3 diffuse, 7 focal). WMT applying a tensor deflection algorithm was used to reconstruct WM tracts adjacent to the lesions. Reconstructed tracts included corticospinal tracts and medial lemnisci. The clinical and imaging follow-up data were also compared and analyzed. FINDINGS: WMT revealed a series of tract alteration patterns including deviation, deformation, infiltration, and apparent tract interruption. WMT reconstructions showed that the major WM tracts were preserved during surgery and improved in position and appearance postoperatively. These findings correlated with the improvement or preservation of neurological function as determined by clinical assessment. CONCLUSIONS: Compared with the information provided by conventional MR imaging, DTI and WMT provided superior quantification and visualization of lesion involvement in eloquent fibre tracts of the brainstem. Moreover, DTI and WMT were found to be beneficial for white matter recognition in the neurosurgical planning and postoperative assessment of brainstem lesions. |
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Authors:
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X Chen; D Weigel; O Ganslandt; M Buchfelder; C Nimsky |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-23 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 149 ISSN: 0942-0940 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-11-13 Completed Date: 2008-01-18 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 1117-31; discussion 1131 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, University Erlangen-Nürnberg, Erlangen, Germany. chen@nch.imed.uni-erlangen.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Astrocytoma / diagnosis*, pathology, surgery Brain Damage, Chronic / diagnosis, pathology, surgery Brain Mapping* Brain Stem Neoplasms / diagnosis*, pathology, surgery Cranial Nerve Diseases / diagnosis, pathology Diffusion Magnetic Resonance Imaging* Dominance, Cerebral / physiology Female Hemangioma, Cavernous, Central Nervous System / diagnosis*, pathology, surgery Humans Image Processing, Computer-Assisted* Imaging, Three-Dimensional* Male Middle Aged Nerve Fibers, Myelinated / pathology* Nerve Net / pathology*, surgery Neurologic Examination Neuronavigation* Pons / pathology*, surgery Postoperative Complications / diagnosis, pathology Pyramidal Tracts / pathology, surgery |
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