Document Detail

Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia.
MedLine Citation:
PMID:  16035194     Owner:  NLM     Status:  MEDLINE    
Recent evidence from neuroimaging studies suggests that neural dysfunction is involved in the pathophysiology of schizophrenia. Diffusion tensor imaging (DTI) is a technique that has the potential to detect subtle disruptions of neural connectivity. Fractional anisotropy (FA), which is measured by DTI, is a measure of the directionality of diffusion anisotropy. Decrease in FA indicates abnormalities of white matter due to increased water diffusion accompanied by an increase in extracellular space. In the literature, previous studies reported that patients with schizophrenia showed widespread lower FA in the white matter. These findings suggest that patients with schizophrenia have microstructural lesions in the cerebral white matter. We used DTI to determine whether neural connectivity was disturbed in the middle cerebellar peduncles in schizophrenic subjects. We found a significant FA reduction in the middle cerebellar peduncle in patients with schizophrenia. Therefore, neural disconnectivity between the cerebellum and cerebrum was considered present in patients with schizophrenia and may be involved in the pathology of schizophrenia. This review provides current findings regarding DTI study on the cerebellar peduncle in patients with schizophrenia.
Gaku Okugawa; Kenji Nobuhara; Tatsuya Sugimoto; Toshihiko Kinoshita
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cerebellum (London, England)     Volume:  4     ISSN:  1473-4222     ISO Abbreviation:  Cerebellum     Publication Date:  2005  
Date Detail:
Created Date:  2005-07-22     Completed Date:  2005-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101089443     Medline TA:  Cerebellum     Country:  England    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan.
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MeSH Terms
Analysis of Variance
Diffusion Magnetic Resonance Imaging / methods*
Functional Laterality
Mesencephalon / metabolism,  pathology*
Schizophrenia / metabolism,  pathology*

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