Document Detail

Diffusion tensor imaging study of the anterior limb of internal capsules in neuroleptic-naive schizophrenia.
MedLine Citation:
PMID:  18280926     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: Abnormalities in brain structure have been implicated in psychosis. Herein, we investigated the differences in fractional anisotropy (FA) and average diffusion coefficient (ADC) in the bilateral anterior limb of internal capsules between neuroleptic-naive schizophrenic patients and appropriately matched healthy controls. MATERIALS AND METHODS: Magnetic resonance imaging was performed with a 1.5 T superconductive MR scanner, and diffusion tensor imaging was carried out in 21 neuroleptic-naive schizophrenic patients and 18 matched healthy controls. FA and ADC were measured by region of interest analysis. RESULTS: Compared with healthy controls, the neuroleptic-naive schizophrenic patients showed significantly reduced FA in the bilateral anterior limb of the internal capsule. However, the difference in the ADC values between the patients and the controls was not significant. CONCLUSIONS: FA of the bilateral anterior limb of the internal capsule was reduced in neuroleptic-naive schizophrenic patients, indicating that the integrity of the white matter of the bilateral thalamus-frontal connection or the bilateral thalamus-anterior cingulate gyrus connection was destroyed.
Li-qiu Zou; Jing-xia Xie; Hui-shu Yuan; Xin-long Pei; Wen-tian Dong; Peng-cheng Liu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  15     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-05-30     Revised Date:  2008-06-24    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  285-9     Citation Subset:  IM    
Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100083, P.R. China.
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MeSH Terms
Antipsychotic Agents
Case-Control Studies
Diffusion Magnetic Resonance Imaging / methods*
Gyrus Cinguli / pathology
Image Processing, Computer-Assisted / methods
Internal Capsule / pathology*
Middle Aged
Prefrontal Cortex / pathology
Schizophrenia / pathology*
Thalamus / pathology
Reg. No./Substance:
0/Antipsychotic Agents
Erratum In:
Acad Radiol. 2008 Jun;15(6):811

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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