Document Detail

Diffusion tensor imaging for predicting hand motor outcome in chronic stroke patients.
MedLine Citation:
PMID:  22429352     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: Previous studies have indicated that diffusion tensor imaging (DTI) values are related to clinical outcome in stroke patients. This prospective study explored whether DTI values were predictive for hand function outcome in chronic stroke patients.
METHODS: The DTI parameters (rλ(1), rλ(23), fractional anisotropy [rFA] and mean diffusivity [rMD]) were investigated in patients with completely paralysed hands (CPH; n = 10) or partially paralysed hands (PPH; n = 10), by two methods of analysis: segment of the corticospinal tract [sCST] analysis; pure region of interest [ROI] analysis. Spearman's correlation coefficient was used to assess the correlation between the DTI parameters and the following clinical measures: Fugl-Meyer Assessment [FMA]; National Institutes of Health Stroke Scale [NIHSS].
RESULTS: Significant differences were found between CPH and PPH for rFA and rλ(23) (sCST analysis) and for rMD and rλ(23) (ROI analysis). The rλ(23) (sCST analysis) correlated with the NIHSS; the rMD (sCST analysis) correlated with the FMA (hand).
CONCLUSION: The three parameters, rFA, rλ(23) and rMD may have predictive value for evaluating hand function outcome in chronic stroke patients.
F Song; F Zhang; D-Z Yin; Y-S Hu; M-X Fan; H-H Ni; X-L Nan; X Cui; C-X Zhou; C-S Huang; Q Zhao; L-H Ma; Y-M Xu; Q-J Xia
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  40     ISSN:  1473-2300     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  126-33     Citation Subset:  IM    
Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, China.
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