| Diffusion tensor imaging of the pediatric optic nerve: intrinsic and extrinsic pathology compared to normal controls. | |
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MedLine Citation:
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PMID: 20578013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To establish normative magnetic resonance diffusion tensor imaging (MRDTI) data in the pediatric optic nerve and compare to pathologic conditions both intrinsic and extrinsic to the anterior optic nerve pathway. MATERIALS AND METHODS: A retrospective analysis of MRDTI at 3.0T in children ages 0-18 with both normal imaging studies and with pathologic conditions either arising from the optic nerves or exerting mass effect on the anterior optic pathways was performed. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values were obtained within the posterior part of the intraorbital optic nerves. Statistical analysis compared normal controls to optic pathway lesions. RESULTS: Lesions intrinsic to the optic nerve including septo-optic dysplasia and optic nerve glioma demonstrated statistically significant reductions in FA and increases in ADC values. There was no statistically significant difference in FA or mean diffusivity between the normal controls and patients with lesions extrinsic to the optic nerve but exerting mass effect on the visual pathway. CONCLUSION: MRDTI is a feasible technique for evaluating the optic nerves in pediatric patients. It may play a role in presurgical planning by demonstrating integrity of the visual pathway in patients with resectable lesions, allowing for minimization of morbidity associated with vision loss. |
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Authors:
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Joshua P Nickerson; Michael B Salmela; Chris J Koski; Trevor Andrews; Christopher G Filippi |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 32 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 76-81 Citation Subset: IM |
Copyright Information:
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(c) 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Fletcher Allen Healthcare/University of Vermont, Burlington, Vermont, USA. Joshua.nickerson@vtmednet.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Analysis of Variance Anisotropy Child Child, Preschool Diffusion Magnetic Resonance Imaging / methods* Humans Infant Infant, Newborn Optic Nerve / anatomy & histology, pathology* Optic Nerve Diseases / pathology* Reference Values Retrospective Studies |
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