Document Detail

Diffusion tensor imaging in preterm infants with punctate white matter lesions.
MedLine Citation:
PMID:  21386750     Owner:  NLM     Status:  MEDLINE    
Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on MRI using tract-based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median GA at birth 30 (25-35) wk, and 23 GA- and sex-matched preterm controls. TBSS and tractography were performed to assess differences in fractional anisotropy (FA) between the two groups at term equivalent age. The impact of lesion load was assessed by performing linear regression analysis of the number of lesions on term MRI versus FA in the corticospinal tracts in the punctate lesions group. FA values were significantly lower in the posterior limb of the internal capsule, cerebral peduncles, decussation of the superior cerebellar peduncles, superior cerebellar peduncles, and pontine crossing tract in the punctate lesions group. There was a significant negative correlation between lesion load at term and FA in the corticospinal tracts (p = 0.03, adjusted r² = 0.467). In conclusion, punctate lesions are associated with altered microstructure in the WM fibers of the corticospinal tract at term equivalent age.
Laura Bassi; Andrew Chew; Nazakat Merchant; Gareth Ball; Luca Ramenghi; James Boardman; Joanna M Allsop; Valentina Doria; Tomoki Arichi; Fabio Mosca; A David Edwards; Frances M Cowan; Mary A Rutherford; Serena J Counsell
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  69     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-09     Completed Date:  2011-08-22     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
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MeSH Terms
Brain / anatomy & histology,  pathology*
Diffusion Tensor Imaging / methods*
Gestational Age
Infant, Newborn
Infant, Premature*
Nerve Fibers, Myelinated / pathology*
Grant Support
MC_U120081323//Medical Research Council; //Medical Research Council

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