| Diffusion tensor imaging in preterm infants with punctate white matter lesions. | |
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MedLine Citation:
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PMID: 21386750 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Our aim was to compare white matter (WM) microstructure in preterm infants with and without punctate WM lesions on magnetic resonance imaging (MRI) using tract based spatial statistics (TBSS) and probabilistic tractography. We studied 23 preterm infants with punctate lesions, median gestational age (GA) at birth 30 (25-35) weeks and 23 GA and sex matched preterm controls. TBSS and tractography were performed to assess differences in fractional anisotropy (FA) between the 2 groups at term equivalent age. The impact of lesion load was assessed by performing linear regression analysis of the number of lesions on term MRI versus FA in the corticospinal tracts in the punctate lesions group. FA values were significantly lower in the posterior limb of the internal capsule, the cerebral peduncles, decussation of the superior cerebellar peduncles, superior cerebellar peduncles and in the pontine crossing tract in the punctate lesions group. There was a significant negative correlation between lesion load at term and FA in the corticospinal tracts (p = 0.03, adjusted r = 0.467). In conclusion, punctate lesions are associated with altered microstructure in the WM fibres of the corticospinal tract at term equivalent age. LIST OF ABBREVIATIONS: |
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Authors:
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Laura Bassi; Andrew Chew; Nazakat Merchant; Gareth Ball; Luca Ramenghi; James Boardman; Joanna M Allsop; Valentina Doria; Tomoki Arichi; Fabio Mosca; A David Edwards; Frances M Cowan; Mary A Rutherford; Serena J Counsell |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-7 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for the Developing Brain [A.C., N.M., G.B., J.B., J.M.A., V.D., T.A., A.D.E., F.M.C., M.A.R., S.J.C.], Imperial College and MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0HS, United Kingdom; Department of Maternal and Paediatric Sciences [L.B., L.R., F.M.], Fondazione IRCCS a Grande Ospedale Maggiore Policlinico, University of Milan, Milano 20122, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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