| Diffusion tensor imaging in patients with adult chronic idiopathic hydrocephalus. | |
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MedLine Citation:
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PMID: 20404696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Diffusion tensor imaging (DTI) parameters were investigated in patients with chronic idiopathic hydrocephalus to evaluate microstructural changes of brain tissue caused by chronic ventricular dilatation. METHODS: Eleven patients fulfilling the criteria for possible or probable idiopathic normal pressure hydrocephalus and 10 healthy control subjects underwent MRI at 3 Tesla, including DTI with 12 gradient directions. Patients were scanned before lumbar cerebrospinal fluid (CSF) withdrawal tests. Differences in fractional anisotropy (FA) and mean diffusivity (MD) between patients and controls were assessed using 2 different methods: manual definition of regions of interest and a fully automated method, TBSS (Tract-Based Spatial Statistics). DTI parameters were correlated with clinical findings. RESULTS: Compared with the control group, patients with chronic idiopathic hydrocephalus had significantly higher MD values in both the periventricular corticospinal tract (CST) and the corpus callosum (CC), whereas FA values were significantly higher in the CST but lower in the CC. DTI parameters of the CST correlated with the severity of gait disturbances. CONCLUSION: Microstructural changes in periventricular functionally relevant white matter structures (CSF, CC) in chronic idiopathic hydrocephalus can be visualized using DTI. Further studies should investigate the change of DTI parameters after CSF shunting and its relation to neurologic outcome. |
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Authors:
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Elke Hattingen; Alina Jurcoane; Julia Melber; Stella Blasel; Friedhelm E Zanella; Tobias Neumann-Haefelin; Oliver C Singer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurosurgery Volume: 66 ISSN: 1524-4040 ISO Abbreviation: Neurosurgery Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-07-13 Revised Date: 2010-10-20 |
Medline Journal Info:
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Nlm Unique ID: 7802914 Medline TA: Neurosurgery Country: United States |
Other Details:
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Languages: eng Pagination: 917-24 Citation Subset: IM |
Affiliation:
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Institute of Neuroradiology, Goethe University, Frankfurt am Main, Germany. elke.hattingen@kgu.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anisotropy Brain / pathology* Chronic Disease Diffusion Tensor Imaging* Humans Hydrocephalus, Normal Pressure / pathology* Image Interpretation, Computer-Assisted / methods* Middle Aged |
| Comments/Corrections | |
Comment In:
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Neurosurgery. 2010 Nov;67(5):E1474
[PMID:
20871429
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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