Document Detail

Diffusion tensor imaging in patients with essential tremor.
MedLine Citation:
PMID:  17921227     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: The traditional paradigm has regarded essential tremor (ET) as a benign disorder. However, recent clinical, neuroimaging, and neuropathologic studies suggest that ET may be a progressive neurologic disorder. Based on clinicopathologic findings that cerebellum and its outflow are the key structures in ET and degeneration of gray matter in cerebellum is followed by consequent wallerian degeneration of white matter (WM) fibers, the aim of the present study was to investigate changes in anisotropy in patients with ET. MATERIALS AND METHODS: Fractional anisotropy (FA) images were generated from DTI data acquired at 1.5T in 10 patients with ET compared with 8 control subjects by using statistical parametric mapping to make voxel-by-voxel comparisons. RESULTS: Compared with the control subjects, the patients with ET exhibited significantly reduced FA (P(uncorrected) < .005) in the anterolateral portion of the right pons and decreased FA in the bilateral cerebellum, left retrorubral area of the midbrain, and bilateral deep WM, including the orbitofrontal, lateral frontal, parietal, and temporal WM. CONCLUSION: This study demonstrates that structural changes in the WM are extensive in patients with ET, supporting the findings of previous functional neuroimaging and pathologic studies.
D H Shin; B S Han; H S Kim; P H Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-05
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  151-3     Citation Subset:  IM    
Department of Neurology, Ajou University College of Medicine, Suwon, South Korea.
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MeSH Terms
Brain / pathology*
Diffusion Magnetic Resonance Imaging / methods*
Essential Tremor / pathology*
Image Interpretation, Computer-Assisted / methods*
Middle Aged
Nerve Fibers, Myelinated / pathology*
Reproducibility of Results
Sensitivity and Specificity

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