Document Detail

Diffusion tensor imaging in idiopathic acute transverse myelitis.
MedLine Citation:
PMID:  18647886     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our study was based on our hypotheses that in idiopathic acute transverse myelitis (ATM), fractional anisotropy (FA) values would be abnormal not only in the T2-hyperintense lesion but also in the surrounding normal-appearing spinal cord and that the abnormal FA values in the spinal cord could be related to clinical outcome. SUBJECTS AND METHODS: Sagittal diffusion tensor imaging (DTI) was performed in 10 patients with idiopathic ATM (four men, six women; mean age, 45 years; age range, 20-66 years) and 10 sex- and age-matched normal volunteers. FA measurements were made in the spinal cord at three levels: lesion, proximal normal-appearing spinal cord, and distal normal-appearing spinal cord. The grade of FA decrease (mild, less than 10% decrease [(FA normal - FA pt) x 100 / FA normal]; moderate, 10-20%; severe, more than 20%) was related to the clinical outcome, which was determined by a neurologist using Paine's scale of normal, good, fair, or poor. RESULTS: Mean FA values in patients were significantly lower than those in normal volunteers in lesions (0.5328 vs 0.7125, p = 0.002) and distal normal-appearing spinal cord (0.6676 vs 0.7720, p = 0.0137). All three patients with a mild FA decrease or increase in distal normal-appearing spinal cord showed a normal or good outcome, but all three patients with a severe FA decrease in distal normal-appearing spinal cord showed a fair outcome, among the eight patients to whom steroid treatment was given. CONCLUSION: FA values in lesions and in distal normal-appearing spinal cord significantly decreased in patients with idiopathic ATM, and FA decrease in distal normal-appearing spinal cord might be related to clinical outcome.
Joon Woo Lee; Kyung Seok Park; Jae Hyoung Kim; Ja-Young Choi; Sung Hwan Hong; Seong-Ho Park; Heung Sik Kang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  191     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-23     Completed Date:  2008-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  W52-7     Citation Subset:  AIM; IM    
Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
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MeSH Terms
Case-Control Studies
Cervical Vertebrae
Diffusion Magnetic Resonance Imaging*
Middle Aged
Myelitis, Transverse / pathology*
Statistics, Nonparametric

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