| Diffusion tensor imaging demonstrates focal lesions of the corticospinal tract in hemiparetic patients with cerebral palsy. | |
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MedLine Citation:
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PMID: 17512661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to use diffusion tensor imaging (DTI) with fiber tractography (FT) to demonstrate focal lesions of the corticospinal tract (CST) in hemiparetic patients with cerebral palsy (CP) who showed no specific focal lesions on conventional brain MRI. Four hemiparetic patients with CP (three left hemiparesis, mean age: 2.5 years, range: 0.9-7.0) and four age-matched controls were recruited. DTI was performed using a 1.5-T system with a synergy-L Sensitivity Encoding head coil. Fractional anisotropy (FA) and apparent diffusion coefficients (ADC) were measured using the region of interest (ROI) method. We estimated the asymmetric anisotropy index (AA) and asymmetric mean diffusivity index (AD) to evaluate the asymmetry between right and left CSTs. All four patients showed interrupted FT at the affected periventricular white matter (PVWM) level compared to that of the opposite side; this was not detected on conventional brain MRI and explained the hemiparesis of these patients. Compared to the data of controls, all patients showed significant AA and AD only at the PVWM level. DTI with FT demonstrated focal lesions at the PVWM level. We conclude that DTI with FT may be a useful modality for investigating focal lesions in hemiparetic patients with CP. |
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Authors:
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Su Min Son; Young Hwan Ahn; Joon Sakong; Han Ku Moon; Sang Ho Ahn; Ho Lee; In Kyu Yu; Youn Jeong Shin; Sung Ho Jang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-04-27 |
Journal Detail:
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Title: Neuroscience letters Volume: 420 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-28 Completed Date: 2009-06-02 Revised Date: 2009-06-23 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 34-8 Citation Subset: IM |
Affiliation:
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Department of Physical Medicine and Rehabilitation, School of Medicine, Eulji University, Daejeon, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anisotropy Cerebral Palsy / pathology* Child Child, Preschool Diffusion Magnetic Resonance Imaging Female Functional Laterality / physiology Humans Image Processing, Computer-Assisted Infant Male Nerve Fibers / pathology Paresis / pathology* Pyramidal Tracts / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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