Document Detail

Diffusion tensor fractional anisotropy of the normal-appearing seven segments of the corpus callosum in healthy adults and relapsing-remitting multiple sclerosis patients.
MedLine Citation:
PMID:  15906348     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the utility of whole-brain diffusion tensor imaging (DTI) in elucidating the pathogenesis of multiple sclerosis (MS) using the normal-appearing white matter (NAWM) of the corpus callosum (CC) as a marker of occult disease activity. MATERIALS AND METHODS: A high signal-to-noise ratio (SNR) and optimized entire brain DTI data were acquired in 26 clinically-definite relapsing and remitting multiple sclerosis (RRMS) patients and 32 age-matched healthy adult controls. The fractional anisotropy (FA) values of seven functionally distinct regions in the normal-appearing CC were compared between patients and controls. RESULTS: This study indicates that 1) there was a gender-independent FA heterogeneity of the functionally specialized CC segments in normal volunteers; 2) FA in the MS group was significantly decreased in the anterior (P=0.0039) and posterior (P=0.0018) midbody subdivisions of the CC, possibly due to a reduction of small-caliber axons; and 3) the FA of the genu of the CC was relatively intact in the MS patients compared to the healthy age-matched controls (P=0.644), while the splenium showed an insignificant trend of reduced FA values (P=0.248). The decrease in FA in any of the CC subdivisions did not correlate with disease duration (DD) or the expanded disability status scale (EDSS) score. CONCLUSION: The preliminary results are consistent with published histopathology and clinical studies on MS, but not with some published DTI reports. This study provides insights into the pathogenesis of MS, and the role played by compromised axonal integrity in this disease.
Khader M Hasan; Rakesh K Gupta; Rafael M Santos; Jerry S Wolinsky; Ponnada A Narayana
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Publication Detail:
Type:  Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  21     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-25     Completed Date:  2005-09-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  735-43     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 Wiley-Liss, Inc.
Department of Interventional and Diagnostic Imaging, University of Texas Medical School at Houston, Houston, Texas, USA.
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MeSH Terms
Analysis of Variance
Case-Control Studies
Chi-Square Distribution
Corpus Callosum / pathology*
Diffusion Magnetic Resonance Imaging / methods*
Image Processing, Computer-Assisted
Multiple Sclerosis, Relapsing-Remitting / pathology*
Grant Support

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