| Diffusion tensor fractional anisotropy of the normal-appearing seven segments of the corpus callosum in healthy adults and relapsing-remitting multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 15906348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the utility of whole-brain diffusion tensor imaging (DTI) in elucidating the pathogenesis of multiple sclerosis (MS) using the normal-appearing white matter (NAWM) of the corpus callosum (CC) as a marker of occult disease activity. MATERIALS AND METHODS: A high signal-to-noise ratio (SNR) and optimized entire brain DTI data were acquired in 26 clinically-definite relapsing and remitting multiple sclerosis (RRMS) patients and 32 age-matched healthy adult controls. The fractional anisotropy (FA) values of seven functionally distinct regions in the normal-appearing CC were compared between patients and controls. RESULTS: This study indicates that 1) there was a gender-independent FA heterogeneity of the functionally specialized CC segments in normal volunteers; 2) FA in the MS group was significantly decreased in the anterior (P=0.0039) and posterior (P=0.0018) midbody subdivisions of the CC, possibly due to a reduction of small-caliber axons; and 3) the FA of the genu of the CC was relatively intact in the MS patients compared to the healthy age-matched controls (P=0.644), while the splenium showed an insignificant trend of reduced FA values (P=0.248). The decrease in FA in any of the CC subdivisions did not correlate with disease duration (DD) or the expanded disability status scale (EDSS) score. CONCLUSION: The preliminary results are consistent with published histopathology and clinical studies on MS, but not with some published DTI reports. This study provides insights into the pathogenesis of MS, and the role played by compromised axonal integrity in this disease. |
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Authors:
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Khader M Hasan; Rakesh K Gupta; Rafael M Santos; Jerry S Wolinsky; Ponnada A Narayana |
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Publication Detail:
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Type: Clinical Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 21 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-25 Completed Date: 2005-09-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 735-43 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 Wiley-Liss, Inc. |
Affiliation:
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Department of Interventional and Diagnostic Imaging, University of Texas Medical School at Houston, Houston, Texas, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Anisotropy Case-Control Studies Chi-Square Distribution Corpus Callosum / pathology* Diffusion Magnetic Resonance Imaging / methods* Female Humans Image Processing, Computer-Assisted Male Multiple Sclerosis, Relapsing-Remitting / pathology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB02095/EB/NIBIB NIH HHS; R01 NS31499/NS/NINDS NIH HHS |
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