Document Detail

Diffusion tensor changes in patients with amnesic mild cognitive impairment and various dementias.
MedLine Citation:
PMID:  19442496     Owner:  NLM     Status:  MEDLINE    
White matter damage and its contribution to clinical manifestations in patients with dementia have been increasingly recognized. To explore white matter changes in different types of dementia, we examined brain water diffusivity with diffusion tensor imaging (DTI). We measured fractional anisotropy and mean diffusivity of multiple white matter regions in patients with amnesic mild cognitive impairment (MCI, n=10), Alzheimer's disease (AD, n=30), subcortical ischemic vascular dementia (SIVD, n=18), frontotemporal dementia (FTD, n=7), and control subjects (n=20). We performed pairwise comparisons in each region of interest between patients and controls. MCI patients showed diffusion tensor change (DTC) in the left anterior periventricular (PV) area, possibly in the right posterior PV area, and the genu of the corpus callosum. AD patients showed DTC in the corpus callosum, and in frontal and parieto-occipital subcortical and anterior PV areas. In SIVD patients, DTC occurred in the genu of the corpus callosum, and in bilateral frontal subcortical and PV areas. FTD patients differed from controls in showing DTC in the temporal and frontal subcortical areas, the genu of the corpus callosum and PV areas. The degree of DTC correlated with the clinical severity of dementia as assessed by the clinical dementia rating (CDR). Mean diffusivity was diffusely and positively associated with the CDR scores. Fractional anisotropy of the PV areas was negatively associated with the CDR scores, suggesting a critical role of the lateral cholinergic pathways.
Ta-Fu Chen; Chih-Chun Lin; Ya-Fang Chen; Hon-Man Liu; Mau-Sun Hua; Yung-Chien Huang; Ming-Jang Chiu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-12
Journal Detail:
Title:  Psychiatry research     Volume:  173     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-08-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Department of Neurology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / pathology
Amnesia / pathology*,  psychology
Brain / pathology*
Brain Mapping / methods
Cognition Disorders / pathology*,  psychology
Corpus Callosum / pathology
Dementia / classification,  pathology*,  psychology
Dementia, Vascular / pathology
Diffusion Magnetic Resonance Imaging*
Image Processing, Computer-Assisted
Middle Aged
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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