Document Detail

Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia.
MedLine Citation:
PMID:  11102575     Owner:  NLM     Status:  MEDLINE    
In a model of experimental stroke, we characterize the effects of mild hypothermia, an effective neuroprotectant, on fluid shifts, cerebral perfusion and spreading depression (SD) using diffusion- (DWI) and perfusion-weighted MRI (PWI). Twenty-two rats underwent 2 h of middle cerebral artery (MCA) occlusion and were either kept normothermic or rendered mildly hypothermic shortly after MCA occlusion for 2 h. DWI images were obtained 0.5, 2 and 24 h after MCA occlusion, and maps of the apparent diffusion coefficient (ADC) were generated. SD-like transient ADC decreases were also detected using DWI in animals subjected to topical KCl application (n=4) and ischemia (n=6). Mild hypothermia significantly inhibited DWI lesion growth early after the onset of ischemia as well as 24 h later, and improved recovery of striatal ADC by 24 h. Mild hypothermia prolonged SD-like ADC transients and further decreased the ADC following KCl application and immediately after MCA occlusion. Cerebral perfusion, however, was not affected by temperature changes. We conclude that mild hypothermia is neuroprotective and suppresses infarct growth early after the onset of ischemia, with better ADC recovery. The ADC decrease during SD was greater during mild hypothermia, and suggests that the source of the ADC is more complex than previously believed.
M A Yenari; D Onley; M Hedehus; A deCrespigny; G H Sun; M E Moseley; G K Steinberg
Related Documents :
10371525 - Evaluation of early reperfusion and i.v. tpa therapy using diffusion- and perfusion-wei...
21084415 - Diffusion-weighted mr imaging of the placenta in fetuses with placental insufficiency.
18972355 - Comparison and reproducibility of adc measurements in breathhold, respiratory triggered...
15377805 - Thrombotic thrombocytopenic purpura-induced posterior leukoencephalopathy in a patient ...
17704705 - Mri scanners and the stapes prosthesis.
7993265 - Distended iliopsoas bursa: case reports and anatomical dissection.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  885     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-03-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  208-19     Citation Subset:  IM    
Department of Neurosurgery, Stanford University Medical Center, 120 Welch Road, HSLS Bldg. P304, Stanford, CA 94305-5487, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Temperature / physiology
Brain Ischemia / diagnosis,  etiology,  prevention & control*
Cerebral Cortex / pathology
Cortical Spreading Depression* / physiology
Hypothermia, Induced* / methods
Infarction, Middle Cerebral Artery / complications
Magnetic Resonance Imaging / methods*
Rats, Sprague-Dawley
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Degree of immediate early gene induction in striatum by eticlopride determines sensitivity to N-meth...
Next Document:  Manganese induces neurite outgrowth in PC12 cells via upregulation of alpha(v) integrins.