| Diffusion- and perfusion-weighted magnetic resonance imaging of focal cerebral ischemia and cortical spreading depression under conditions of mild hypothermia. | |
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MedLine Citation:
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PMID: 11102575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a model of experimental stroke, we characterize the effects of mild hypothermia, an effective neuroprotectant, on fluid shifts, cerebral perfusion and spreading depression (SD) using diffusion- (DWI) and perfusion-weighted MRI (PWI). Twenty-two rats underwent 2 h of middle cerebral artery (MCA) occlusion and were either kept normothermic or rendered mildly hypothermic shortly after MCA occlusion for 2 h. DWI images were obtained 0.5, 2 and 24 h after MCA occlusion, and maps of the apparent diffusion coefficient (ADC) were generated. SD-like transient ADC decreases were also detected using DWI in animals subjected to topical KCl application (n=4) and ischemia (n=6). Mild hypothermia significantly inhibited DWI lesion growth early after the onset of ischemia as well as 24 h later, and improved recovery of striatal ADC by 24 h. Mild hypothermia prolonged SD-like ADC transients and further decreased the ADC following KCl application and immediately after MCA occlusion. Cerebral perfusion, however, was not affected by temperature changes. We conclude that mild hypothermia is neuroprotective and suppresses infarct growth early after the onset of ischemia, with better ADC recovery. The ADC decrease during SD was greater during mild hypothermia, and suggests that the source of the ADC is more complex than previously believed. |
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Authors:
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M A Yenari; D Onley; M Hedehus; A deCrespigny; G H Sun; M E Moseley; G K Steinberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 885 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-02-22 Completed Date: 2001-03-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 208-19 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Stanford University Medical Center, 120 Welch Road, HSLS Bldg. P304, Stanford, CA 94305-5487, USA. yenari@stanford.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / physiology Brain Ischemia / diagnosis, etiology, prevention & control* Cerebral Cortex / pathology Cortical Spreading Depression* / physiology Diffusion Hypothermia, Induced* / methods Infarction, Middle Cerebral Artery / complications Magnetic Resonance Imaging / methods* Male Perfusion Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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K08 NS01860/NS/NINDS NIH HHS; R01 NS 27292/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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