Document Detail


Diffusion-limited ion flow through pores.
MedLine Citation:
PMID:  999924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
If the permeability of an ion channel is high, the overall transport becomes ultimately limited by the rate with which ions from the aqueous phase arrive at the mouth of the channel. In this study a theoretical treatment of diffusion-limited ion transport through pores is given which takes both concentration and electric potential gradients into account as driving forces for the flow of ions. The current-voltage characteristic of a diffusion-limited channel is found to be strongly saturating. Addition of an impermeable elesults from a reduction in the electric field strength near the mouth of the channel. At low voltages the permeability P of the pore is obtaines as 1/P =(1/Pi)+(1/P'c)+(1/P''c) where Pi is the intrinsic permeability and P'c, P''c are the left-hand and right-hand convergence permeabilities, respectivelyl which are proportional to the aqueous diffusion coefficient of the permeable ion and to the effective capture radius of the pore.
Authors:
P Läuger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  455     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-02-16     Completed Date:  1977-02-16     Revised Date:  2006-04-17    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  493-509     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Biological Transport
Diffusion
Ions
Mathematics
Membranes, Artificial*
Models, Biological
Permeability
Chemical
Reg. No./Substance:
0/Ions; 0/Membranes, Artificial

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