| Diffusion imaging in multiple sclerosis: research and clinical implications. | |
| | |
MedLine Citation:
|
PMID: 20882528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Multiple sclerosis (MS) is an inflammatory-demyelinating and neurodegenerative disease of the central nervous system (CNS) and the most frequent cause of non-traumatic disability in young and middle-age adults. Although conventional MRI (including T2-weighted, pre- and post-contrast T1-weighted scans) has had a huge impact on MS by enabling an earlier diagnosis, and by providing surrogate markers for monitoring treatment response, it is limited by the low pathological specificity and the low sensitivity to diffuse damage in normal-appearing white matter and gray matter. Diffusion weighted MRI is a quantitative technique able to overcome these limitations by providing markers more specific to the underlying pathologic substrates and more sensitive to the full extent of 'occult' brain tissue damage. This review describes diffusion studies in MS, discusses their pathophysiological implications and emphasizes their clinical relevance. |
| | |
Authors:
|
M Inglese; Maxim Bester |
Related Documents
:
|
12356208 - Brain atrophy in multiple sclerosis: impact of lesions and of damage of whole brain tis... 10606798 - The role of magnetic resonance in the assessment of multiple sclerosis. 20086028 - Early mri in optic neuritis: the risk for clinically definite multiple sclerosis. 10773858 - Multiple sclerosis and tonsillectomy: no evidence for an influence on the development o... 12913788 - Helical computed tomography and magnet resonance imaging: diagnosis of pulmonary emboli... 1569878 - Scan time reduction in snapshot flash mri. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: NMR in biomedicine Volume: 23 ISSN: 1099-1492 ISO Abbreviation: NMR Biomed Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2011-01-25 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8915233 Medline TA: NMR Biomed Country: England |
Other Details:
|
Languages: eng Pagination: 865-72 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 John Wiley & Sons, Ltd. |
Affiliation:
|
Department of Radiology, New York University School of Medicine, New York 10016, USA. matilde.inglese@med.nyu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers
/
metabolism Brain / pathology* Central Nervous System / pathology* Diffusion Magnetic Resonance Imaging / methods* Humans Inflammation / pathology Multiple Sclerosis / diagnosis, pathology* Nerve Fibers, Myelinated / pathology* |
| Grant Support | |
ID/Acronym/Agency:
|
R01 NS029029/NS/NINDS NIH HHS; R01 NS051623/NS/NINDS NIH HHS; R01 NS051623-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comprehensive evaluation of time-to-response parameter as a predictor of treatment failure following...
Next Document: Opposing putative roles for canonical and noncanonical NF?B signaling on the survival, proliferation...