Document Detail

Diffusion of fluoride through the rat enamel organ in vitro.
MedLine Citation:
PMID:  3476606     Owner:  NLM     Status:  MEDLINE    
This study investigated the diffusion of fluoride through the enamel organ in vitro. The rat molar explants used were entirely in the secretory stage or predominantly in the maturation stage of enamel formation. The removal of the enamel organ or metabolic inhibition with iodoacetate caused significant increases in enamel fluoride uptake at both stages of enamel formation. Inhibition with dinitrophenol caused a significant increase only in the maturation phase. Uptake of fluoride in enamel was related to the fluoride concentration in the medium, except in the maturation stage explants, where increasing the medium fluoride concentration from 0.05 ppm to 0.08 ppm did not significantly increase fluoride uptake at any of the three observation times. The findings indicate that the enamel organ exists as a diffusion-limiting membrane to the movement of fluoride from the extracellular fluid compartment to the developing enamel.
J W Bawden; T G Deaton; M A Crenshaw
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of dental research     Volume:  66     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-30     Completed Date:  1987-09-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1360-3     Citation Subset:  D; IM    
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MeSH Terms
Age Factors
Dental Enamel / metabolism*
Dinitrophenols / pharmacology
Enamel Organ / metabolism*
Fluorides / administration & dosage,  metabolism*
Fluorine / diagnostic use
Iodoacetates / pharmacology
Iodoacetic Acid
Organ Culture Techniques
Radioisotopes / diagnostic use
Rats, Inbred Strains
Tooth Germ / metabolism*
Grant Support
Reg. No./Substance:
0/Dinitrophenols; 0/Fluorides; 0/Iodoacetates; 0/Radioisotopes; 64-69-7/Iodoacetic Acid; 7782-41-4/Fluorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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