Document Detail

Diffusion-dependent contribution to the slope of the alveolar plateau.
MedLine Citation:
PMID:  3406549     Owner:  NLM     Status:  MEDLINE    
Two healthy subjects performed single breath tests, the inspired gas containing 90% O2, 5% He and 5% SF6. The slope of the alveolar plateau was computed for N2, HE and SF6. The following experimental conditions were considered variable: (1) preinspiratory lung volume (PILV) with inspired volume (VT) equal to 1 L, (2) VT with PILV equal to functional residual capacity (FRC) with and without 10 sec of breath-hold (BH) time, (3) VT with PILV = FRC + 1 L, (4) flow with VT = 1 L and PILV = FRC with and without 10 sec end inspiration BH and (5) BH time with VT = 1 L and PILV = FRC. The slope dependence on the different variables was compared with simulations performed with two multibranch point models of the human acinus with different asymmetries. The model simulations give a coherent picture of all the experimental observations. The present work gives support to previous analyses which suggest that inter-dependence of transport by convection and diffusion in the periphery of the lung is a major component of the slope of the alveolar plateau.
M Paiva; S Verbanck; A van Muylem
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  72     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-09-15     Completed Date:  1988-09-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  257-70     Citation Subset:  IM; S    
Institute of Interdisciplinary Research, Erasme Hospital, Free University of Brussels, Belgium.
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MeSH Terms
Breath Tests
Lung Volume Measurements
Models, Biological
Pulmonary Alveoli / physiology*
Pulmonary Gas Exchange

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