| Diffusion abnormality maps in demyelinating disease: Correlations with clinical scores. | |
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MedLine Citation:
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PMID: 22257426 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Magnetic resonance imaging (MRI) has been explored as a noninvasive tool to assess pathology in multiple sclerosis (MS) patients. However, the correlation between classical MRI measures and physical disability is modest in MS. The diffusion tensor imaging (DTI) MRI technique holds particular promise in this regard. The present study shows brain regions where FA and individual diffusivities abnormalities are present and check their correlations with physical disability clinical scores. METHODS: Eight patients and 12 matched healthy controls were recruited. The Multiple Sclerosis Functional Composite was administered. For MR-DTI acquisitions, a Genesis Signa 1.5T MR system, an EP/SE scanning sequence, 25 gradient directions were used. RESULTS: Tract Based Spatial Statistics (TBSS) group comparisons showed reduced FA and increased individual diffusivities in several brain regions in patients. Significant correlations were found between FA and: EDSS, 9-HPT(NON)DOM and 25FW score; between λ(2) and: P100 (r&l), 9-HPT(NON)DOM and 25FW; between λ(3) and: 9-HPT(NON)DOM and 25FW score. CONCLUSIONS: Fractional anisotropy and individual radial diffusivities proved to be important markers of motor disabilities in MS patients when the disease duration mean and the disability scores values range are relatively high. |
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Authors:
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Mihaela Onu; Adina Roceanu; Uta Sboto-Frankenstein; Robert Bendic; Eugen Tarta; Florentin Preoteasa; Ovidiu Bajenaru |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: European journal of radiology Volume: - ISSN: 1872-7727 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106411 Medline TA: Eur J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Medical Imaging Department, Clinical Hospital "Prof. Dr. Th. Burghele", Panduri street 20, Bucharest 050659, Romania; Biophysics Department, University of Medicine and Pharmacy "Carol Davila", Eroilor Sanitari Blvd. 8, Bucharest 050474, Romania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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