| Diffusion Tensor Imaging in Pediatric Spinal Cord Injury: Preliminary Examination of Reliability and Clinical Correlation. | |
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MedLine Citation:
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PMID: 22210015 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Study Design. The design was a non-experimental, repeated measures design.Objective. To examine the reliability of repeated diffusion tensor imaging (DTI) values of the pediatric cord and to compare DTI values with values obtained on the clinical examination and findings from conventional MRI.Summary of Background Data. DTI quantifies the diffusion of water molecules in directions parallel and transverse to the plane of neuronal axons. The unique characteristic architecture of the spinal cord allows DTI to examine the white matter and potentially separate white matter from gray matter and assess structural damage of the cord.Methods. 10 youths with cervical SCI were evaluated using the International Standards for Neurological Classification of SCI (ISNCSCI) and had two scans using a 3.0T Siemens Verio MR scanner. The imaging protocol consisted of conventional sagittal Fast Spin Echo (FSE) T1-and T2-weighted scans, axial FSE T2 weighted scans and axial DTI acquisition. Intraclass Correlation Coefficient (ICC) and 95% Confidence Interval (CI) were calculated for mean, axial and radial diffusivity (MD, AD, RD, respectively) and fractional anisotropy (FA). Relationships among DTI, MRI and ISNCSCI were evaluated using Spearman Correlation Coefficients (rs) and differences were tested using Cohen's method.Results. There was moderate-to-strong reliability (ICC = 0.75-0.95) for MD, AD and RD for all spinal levels. Reliability for FA for mid C4, and between C5-6 and C7-T1 was moderate (ICC = 0.75-0.80). Diffusivity values demonstrated moderate to good negative relationships (rs = -0.30 -0.59) with four ISNCSCI values. FA values had a moderate-to-good (rs = 0.33-0.53) positive relationship with five ISNCSCI values. Compared to MRI, DTI values had significantly stronger correlations (p = <.0001) with the majority of ISNCSCI values.Conclusion. DTI values had good-to-strong reliability on repeated scans and moderate-to-good concurrent validity with clinical scores. When compared to conventional MRI, DTI values had statistically stronger correlations with the majority of values from the clinical examination. |
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Authors:
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Mj Mulcahey; Amer Samdani; John Gaughan; Nadia Barakat; Scott Faro; Randal R Betz; Jurgen Finsterbusch; Feroze B Mohamed |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-28 |
Journal Detail:
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Title: Spine Volume: - ISSN: 1528-1159 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7610646 Medline TA: Spine (Phila Pa 1976) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Shriners Hospitals for Children Philadelphia, Pediatric Research Center for Neural Repair and Rehabilitation, Philadelphia, PA 2Temple University School of Medicine, Biostatistical Consulting Center, Philadelphia, PA 3Temple University, Department of Radiology, Philadelphia PA 4University Medical Center Hamburg-Eppendorf, Hamburg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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