| Diffusion Tensor Imaging Analysis of Tumefactive Giant Brain Lesions in Multiple Sclerosis. | |
| | |
MedLine Citation:
|
PMID: 22273156 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: Diffusion tensor imaging (DTI) quantifies the motion of water within brain tissue. Inflammation leads to tissue disruption, resulting in increased diffusivity and decreased directionality. We aimed to quantify the damage within tumefactive giant brain lesions (TGL) in multiple sclerosis (MS) using MRI and DTI methodology. METHODS: Region of interest were determined on TGL and acute MS lesions to obtain metrics such as volume, apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity ((||) ), and radial diffusivity ((⊥) ). RESULTS: We identified 10 TGL in 10 patients with MS. The incidence of TGL was 2.8%. Comparing TGL to acute 16 MS lesions, DTI metrics demonstrated significantly higher ADC, (||) and (⊥) diffusivities and lower FA values in TGL (P <.001). Five TGL were reevaluated after 120 days by MRI and DTI metrics. Significant group changes were detected at 120 days: TGL volume decreased, ADC, (||) and (⊥) values were lower and FA was higher (P < .01). CONCLUSIONS: Within the spectrum of acute MS lesions, TGL present DTI metrics of an intense acute inflammatory process. Analysis of TGL progression proposes that DTI metrics sensitively detects micro-structural changes in TGL from acute inflammation towards lesion recovery and reorganization. J Neuroimaging 2012;XX:1-7. |
| | |
Authors:
|
Shmuel Miron; Sigal Tal; Anat Achiron |
Related Documents
:
|
7554666 - Fe-52 imaging of intrathoracic extramedullary hematopoiesis in a patient with beta-thal... 22396226 - A novel mri-compatible brain ventricle phantom for validation of segmentation and volum... 8247196 - Clinical evaluation of 99mtc diaminocyclohexane, a renal tubular agent with cationic tr... 1992026 - Comparison of in vitro rbc labeling with the ultratag rbc kit versus in vivo labeling. 11709466 - Spiral ct venography of the lower extremities by injection via an arm vein in patients ... 21031516 - 4d time-resolved magnetic resonance angiography for noninvasive assessment of pulmonary... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
|
Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: - ISSN: 1552-6569 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 by the American Society of Neuroimaging. |
Affiliation:
|
From the Multiple Sclerosis Center, Sheba Medical Center, Ramat-Gan, Israel (SM, AA); Radiology Department, Sheba Medical Center, Ramat-Gan, Israel (ST). |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Emergency department visits, ambulance calls, and mortality associated with an exceptional heat wave...
Next Document: Development of an Instrument for a Primary Airway Provider's Performance With an ICU Multidisciplina...