Document Detail

Diffusion MR imaging of hypoglycemic encephalopathy.
MedLine Citation:
PMID:  19875472     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: MR imaging features of HE have not been fully established. The purpose of this study was to determine the topographic distribution and DWI findings of HE. MATERIALS AND METHODS: We retrospectively evaluated HE MR imaging (n = 11). The topographic distribution of the lesions was evaluated on routine MR imaging, and DWI SI and ADC values were assessed. The ADC value of involved lesions was compared with the noninvolved subcortical WM area by use of the paired t test. RESULTS: MR images demonstrated bilateral diffusion-restrictive lesions in the posterior limb of the IC (n = 6), cerebral cortex (n = 8), CR (n = 7), CS (n = 9), hippocampus (n = 4), and BG (n = 1). The mean ADC value of lesions was 448.82 +/- 92.34 x 10(-6) mm(2)/s compared with the mean ADC value of noninvolved lesions (837.72 +/- 62.14 x 10(-6) mm(2)/s); this difference was statistically significant (P < .000). The lesions showed complete resolution on follow-up DWI for 6 patients. Three patients with cortical involvement of > or = 2 lobes showed partial recovery or death, but most of the other patients with WM involvement or cortical involvement in only 1 lobe experienced complete recovery. CONCLUSIONS: The topographic localization of the lesions was the posterior limb of the IC, cerebral cortex, CR, CS, hippocampus, and BG. Most HE lesions probably correspond to areas of reversible cytotoxic edema as seen on DWI, which can predict the prognosis of HE according to the degree of lesion extent.
E G Kang; S J Jeon; S S Choi; C J Song; I K Yu
Publication Detail:
Type:  Journal Article     Date:  2009-10-29
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  31     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-16     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  IM    
Department of Radiology, Wonkwang University Hospital, Chunbuk, Republic of Korea.
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MeSH Terms
Basal Ganglia / metabolism,  pathology
Blood Glucose / metabolism
Brain / metabolism,  pathology
Brain Diseases, Metabolic / metabolism*,  pathology*
Brain Edema / metabolism,  pathology
Cerebral Cortex / metabolism,  pathology
Diffusion Magnetic Resonance Imaging*
Hippocampus / metabolism,  pathology
Hypoglycemia / metabolism*,  pathology*
Internal Capsule / metabolism,  pathology
Middle Aged
Predictive Value of Tests
Retrospective Studies
Reg. No./Substance:
0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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