| Diffusion Fractional Anisotropy-based Transformation in Skeletal Muscle Caused by Pressure. | |
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MedLine Citation:
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PMID: 23037562 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Purpose: We used diffusion tensor imaging (DTI) to evaluate anisotropic changes in skeletal muscle cells under external pressure. Materials and Methods: In 6 healthy volunteers, we compared DTI of the tibialis anterior (TA) and soleus (SOL) muscles under pressure. We performed imaging using a 1.5-tesla magnetic resonance (MR) scanner and diffusion-weighted stimulated-echo echo-planar pulse sequences optimized for skeletal muscle. We calculated diffusion tensor eigenvalues (λ), apparent diffusion coefficients, and fractional anisotropy (FA) values in a series of axially acquired DTI and compared them between the pressurized and nonpressurized lower limbs. We also measured a cross-sectional area of skeletal muscle. Results: We observed clear differences in FA and λ(3) between pressurized muscles and the nonpressurized muscles we used as controls. The mean control FAs were 0.36±0.02 (TA) and 0.30±0.02 (SOL). The mean control λ(3)s were 0.74±0.02 s/mm(2) (TA) and 0.85±0.03 s/mm(2) (SOL). FA values in the pressurized (200 mmHg) limbs increased to 0.39±0.02 (TA) and 0.35±0.04 (SOL) compared with those values in the nonpressurized controls. λ(3) values in the pressurized (200 mmHg) limbs decreased to 0.68±0.05 s/mm(2) (TA) and 0.77±0.06 s/mm(2) (SOL) compared with those in controls. Moreover, the mean value of cross-sectional area of skeletal muscle (control) was 907.3±140.1 mm(2) (TA) and 1522±201.0 mm(2) (SOL). The cross-sectional area in the pressurized (200 mmHg) limbs decreased to 590.3±68.1 mm(2) (TA) and 1131±112.6 mm(2) (SOL) compared with those in controls. One-way analysis of variance (ANOVA) and post hoc Tukey-Kramer tests showed significant differences. Conclusion: Anisotropy changed markedly on pressurizing the lower limb based on the correlation of the cross-sectional area and λ(3) suggested marked changed in anisotropy following application of pressure to the lower limb. If compression of the cross-sectional area is assumed to represent compression of the cell, change in λ(3) reflected the change in the size of muscle cells. |
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Authors:
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Junichi Hata; Kazuo Yagi; Keigo Hikishima; Yuji Komaki; Masami Goto; Keichi Yano |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine Volume: 11 ISSN: 1880-2206 ISO Abbreviation: Magn Reson Med Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-10-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101153368 Medline TA: Magn Reson Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Tokyo Hospital. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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