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Diffusion Fractional Anisotropy-based Transformation in Skeletal Muscle Caused by Pressure.
MedLine Citation:
PMID:  23037562     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Purpose: We used diffusion tensor imaging (DTI) to evaluate anisotropic changes in skeletal muscle cells under external pressure. Materials and Methods: In 6 healthy volunteers, we compared DTI of the tibialis anterior (TA) and soleus (SOL) muscles under pressure. We performed imaging using a 1.5-tesla magnetic resonance (MR) scanner and diffusion-weighted stimulated-echo echo-planar pulse sequences optimized for skeletal muscle. We calculated diffusion tensor eigenvalues (λ), apparent diffusion coefficients, and fractional anisotropy (FA) values in a series of axially acquired DTI and compared them between the pressurized and nonpressurized lower limbs. We also measured a cross-sectional area of skeletal muscle. Results: We observed clear differences in FA and λ(3) between pressurized muscles and the nonpressurized muscles we used as controls. The mean control FAs were 0.36±0.02 (TA) and 0.30±0.02 (SOL). The mean control λ(3)s were 0.74±0.02 s/mm(2) (TA) and 0.85±0.03 s/mm(2) (SOL). FA values in the pressurized (200 mmHg) limbs increased to 0.39±0.02 (TA) and 0.35±0.04 (SOL) compared with those values in the nonpressurized controls. λ(3) values in the pressurized (200 mmHg) limbs decreased to 0.68±0.05 s/mm(2) (TA) and 0.77±0.06 s/mm(2) (SOL) compared with those in controls. Moreover, the mean value of cross-sectional area of skeletal muscle (control) was 907.3±140.1 mm(2) (TA) and 1522±201.0 mm(2) (SOL). The cross-sectional area in the pressurized (200 mmHg) limbs decreased to 590.3±68.1 mm(2) (TA) and 1131±112.6 mm(2) (SOL) compared with those in controls. One-way analysis of variance (ANOVA) and post hoc Tukey-Kramer tests showed significant differences. Conclusion: Anisotropy changed markedly on pressurizing the lower limb based on the correlation of the cross-sectional area and λ(3) suggested marked changed in anisotropy following application of pressure to the lower limb. If compression of the cross-sectional area is assumed to represent compression of the cell, change in λ(3) reflected the change in the size of muscle cells.
Authors:
Junichi Hata; Kazuo Yagi; Keigo Hikishima; Yuji Komaki; Masami Goto; Keichi Yano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine     Volume:  11     ISSN:  1880-2206     ISO Abbreviation:  Magn Reson Med Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101153368     Medline TA:  Magn Reson Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  179-84     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Tokyo Hospital.
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