Document Detail

Diffuse storage of vegetal wax hydrocarbons of dietary origin. Pathologic and chemical findings in a case.
MedLine Citation:
PMID:  2705874     Owner:  NLM     Status:  MEDLINE    
A 55-year-old man died suddenly, after presenting with unstable angina and an asymptomatic micronodular pulmonary pattern. Autopsy revealed storage of a crystallized fatty substance in the lymph nodes, liver, spleen, adrenal glands, and lungs. In the latter organ, the deposition formed foreign body granulomas, accounting for the radiographic appearance. Mass spectrometry identified the fatty substance as straight-chain saturated hydrocarbons (n-alkanes) of carbon-29 and carbon-31 atoms, which are naturally present in the cuticular wax of many vegetals. The case history and the elimination as causal agent of products manipulated in the patient's work led to the conclusion that the storage was due to excessive consumption of apples, and to a lesser degree of Brussels sprouts. We present the light-microscopic findings and the principal biochemical results. Pathogenic mechanisms are described. As far as we are aware, this is the only observation of vegetal alkane storage to be described to date.
C Duboucher; F Rocchiccioli; A Lageron; A Nègre; R Salvayre; H Bouissou
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  113     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-18     Completed Date:  1989-05-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  423-8     Citation Subset:  AIM; IM    
Department of Pathology, CHU Rangueil, Toulouse, France.
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MeSH Terms
Foreign Bodies / complications,  pathology
Fruit / adverse effects*,  analysis
Granuloma / etiology*,  pathology
Hydrocarbons / adverse effects,  metabolism*
Lung / pathology
Lung Diseases / etiology*,  pathology
Middle Aged
Tissue Distribution
Vegetables / adverse effects,  analysis
Waxes / adverse effects,  metabolism*
Reg. No./Substance:
0/Hydrocarbons; 0/Waxes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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