| Diffuse pulmonary uptake of 99mTc bone-imaging agents: case report and survey. | |
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MedLine Citation:
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PMID: 3899657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the past 5 years, we have encountered 6 cases of diffuse pulmonary uptake of 99m-Tc bone-scanning agents (incidence, 0.04%). To assess the significance of this phenomenon, we reviewed all of the cases reported since 1974 (Including our series, a total of 32 cases). Three groups can be discerned, the first consisting of 24 patients without radiological calcifications in the lungs and with hypercalcemia of different origins (mostly hyperparathyroidism). Of the eight autopsies performed in this group, seven revealed extensive calcifications in alveolar walls and lung vessels; the other autopsy showed no calcification at all and only bronchopneumonic lesions. The second group consists of 6 patients in chronic dialysis. The last group consists of 2 patients having diffuse pulmonary alveolar microlithiasis with extensive radiologic calcifications. The mechanism of lung uptake of 99m-Tc bone-imaging agents is probably the same as that of bone uptake (chemisorption on hydroxyapatite crystals), although other uptake mechanisms have also been discussed. Bone scintigraphy can be useful in the detection of early pulmonary calcifications, which have been associated with impaired pulmonary function and, due to their size, are generally not detected by X-ray. |
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Authors:
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J L Coolens; P Devos; M De Roo |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 11 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1985 |
Date Detail:
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Created Date: 1985-10-29 Completed Date: 1985-10-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 36-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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radionuclide imaging Adult Aged Bone Diseases / radionuclide imaging* Calcinosis / radionuclide imaging* Female Humans Hypercalcemia / radionuclide imaging Lung Diseases / radionuclide imaging* Male Middle Aged Multiple Myeloma / radionuclide imaging Parathyroid Neoplasms / radionuclide imaging Technetium Tc 99m Medronate / diagnostic use* Vitamin D / poisoning |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 63347-66-0/Technetium Tc 99m Medronate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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