| Diffuse pulmonary hemorrhage after streptokinase administration for acute myocardial infarction. | |
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MedLine Citation:
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PMID: 9085336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fibrinolytic drug therapy has markedly reduced morbidity and mortality from acute myocardial infarction. As with any other drug therapy, however, benefits are maximal when patients at higher risk for complications can be identified and treatment decisions modified to reduce the chance of adverse events. Streptokinase, a commonly used and inexpensive thrombolytic, is known to cause both bleeding and immunologic complications, and coexistent conditions predisposing to either are considered relative or absolute contraindications to its use. We report an unusual case of immune-mediated diffuse pulmonary hemorrhage following streptokinase administration for acute myocardial infarction in a patient with pulmonary infection and concurrent cutaneous infection. We propose that these infections constitute additional risk factors and may be used to identify patients at higher risk of this complication from streptokinase. |
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Authors:
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G A Swanson; G Kaeley; S A Geraci |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pharmacotherapy Volume: 17 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 1997 Mar-Apr |
Date Detail:
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Created Date: 1997-05-27 Completed Date: 1997-05-27 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 390-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Tennessee College of Medicine, Memphis, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fibrinolytic Agents
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adverse effects* Hemoptysis / chemically induced* Humans Male Middle Aged Myocardial Infarction / drug therapy* Streptokinase / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.-/Streptokinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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