Document Detail

Diffuse pulmonary hemorrhage after streptokinase administration for acute myocardial infarction.
MedLine Citation:
PMID:  9085336     Owner:  NLM     Status:  MEDLINE    
Fibrinolytic drug therapy has markedly reduced morbidity and mortality from acute myocardial infarction. As with any other drug therapy, however, benefits are maximal when patients at higher risk for complications can be identified and treatment decisions modified to reduce the chance of adverse events. Streptokinase, a commonly used and inexpensive thrombolytic, is known to cause both bleeding and immunologic complications, and coexistent conditions predisposing to either are considered relative or absolute contraindications to its use. We report an unusual case of immune-mediated diffuse pulmonary hemorrhage following streptokinase administration for acute myocardial infarction in a patient with pulmonary infection and concurrent cutaneous infection. We propose that these infections constitute additional risk factors and may be used to identify patients at higher risk of this complication from streptokinase.
G A Swanson; G Kaeley; S A Geraci
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacotherapy     Volume:  17     ISSN:  0277-0008     ISO Abbreviation:  Pharmacotherapy     Publication Date:    1997 Mar-Apr
Date Detail:
Created Date:  1997-05-27     Completed Date:  1997-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8111305     Medline TA:  Pharmacotherapy     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  390-4     Citation Subset:  IM    
Department of Internal Medicine, University of Tennessee College of Medicine, Memphis, USA.
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MeSH Terms
Fibrinolytic Agents / adverse effects*
Hemoptysis / chemically induced*
Middle Aged
Myocardial Infarction / drug therapy*
Streptokinase / adverse effects*
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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