Document Detail

Diffuse panbronchiolitis: histologic diagnosis in unsuspected cases involving North American residents of Asian descent.
MedLine Citation:
PMID:  9499359     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study and report two cases of diffuse panbronchiolitis in patients of Asian ancestry residing in the United States and to review the literature pertaining to this disease. DESIGN: Diffuse panbronchiolitis is a progressive interstitial pneumonitis occurring primarily in Japan. Rare cases are now being identified in Europe and North America. Patients often have a history of sinusitis, present with dyspnea on exertion, and show a restrictive pattern on pulmonary function tests. The clinical, radiologic, and pathologic features of two cases of the disease received for consultation at the Armed Forces Institute of Pathology, Washington, DC, are reported with a review of the literature. RESULTS: Chest radiographs revealed bilateral small nodular opacities with ill-defined borders. High-resolution computed tomography demonstrated the abnormalities to have a centrilobular distribution. Histologically, there was transmural chronic inflammation centered on the terminal bronchioles and an interstitial infiltrate of foamy macrophages. CONCLUSION: Diffuse panbronchiolitis may be mistaken for other more common small airway diseases and may be underrecognized in Western nations. The immigration of Asians and sporadic case reports involving non-Asians make recognition of this disease entity important, as the implications for therapy are different than that of other small airway diseases.
M S Fisher; W L Rush; M L Rosado-de-Christenson; E R Goldstein; S M Tomski; J M Wempe; W D Travis
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  122     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-06     Completed Date:  1998-03-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  156-60     Citation Subset:  AIM; IM    
Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base, Tex, USA.
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MeSH Terms
Asia / ethnology
Bronchiolitis / pathology*,  radiography
Diagnosis, Differential
Lung Diseases, Interstitial / pathology*,  radiography
North America / epidemiology
Tomography, X-Ray Computed
Erratum In:
Arch Pathol Lab Med 1998 May;122(5):446

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