Document Detail


Diffuse osteosclerosis in hairy cell leukemia.
MedLine Citation:
PMID:  2804348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We describe two patients with a new clinical pathologic syndrome of diffuse osteosclerosis in association with hairy cell leukemia. In both patients bone marrow biopsies could not be obtained due to extremely hard bones and inability to insert the biopsy needle; neither patient had a history of bony pain or fracture. The osteosclerotic process in one patient stabilized after successful treatment of her hairy cell leukemia with interferon alpha and deoxycoformycin suggesting that the osteosclerosis observed was related to the underlying malignant disease. Possible etiologic mechanisms are discussed.
Authors:
L A VanderMolen; W J Urba; D L Longo; J Lawrence; H Gralnick; R G Steis
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  74     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1989-12-08     Completed Date:  1989-12-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2066-9     Citation Subset:  AIM; IM    
Affiliation:
Biological Response Modifiers Program, National Cancer Institute, Frederick, MD 21701.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Leukemia, Hairy Cell / complications*
Male
Middle Aged
Osteosclerosis / complications*,  pathology,  radiography
Grant Support
ID/Acronym/Agency:
N01-CO-74102/CO/NCI NIH HHS

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