| Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury. | |
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MedLine Citation:
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PMID: 19566308 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used a nonimpact inertial rotational model of a closed head injury in neonatal piglets to simulate the conditions following traumatic brain injury in infants. Diffuse optical techniques, including diffuse reflectance spectroscopy and diffuse correlation spectroscopy (DCS), were used to measure cerebral blood oxygenation and blood flow continuously and noninvasively before injury and up to 6 h after the injury. The DCS measurements of relative cerebral blood flow were validated against the fluorescent microsphere method. A strong linear correlation was observed between the two techniques (R=0.89, p<0.00001). Injury-induced cerebral hemodynamic changes were quantified, and significant changes were found in oxy- and deoxy-hemoglobin concentrations, total hemoglobin concentration, blood oxygen saturation, and cerebral blood flow after the injury. The diffuse optical measurements were robust and also correlated well with recordings of vital physiological parameters over the 6-h monitoring period, such as mean arterial blood pressure, arterial oxygen saturation, and heart rate. Finally, the diffuse optical techniques demonstrated sensitivity to dynamic physiological events, such as apnea, cardiac arrest, and hypertonic saline infusion. In total, the investigation corraborates potential of the optical methods for bedside monitoring of pediatric and adult human patients in the neurointensive care unit. |
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Authors:
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Chao Zhou; Stephanie A Eucker; Turgut Durduran; Guoqiang Yu; Jill Ralston; Stuart H Friess; Rebecca N Ichord; Susan S Margulies; Arjun G Yodh |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical optics Volume: 14 ISSN: 1083-3668 ISO Abbreviation: J Biomed Opt Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-07-01 Completed Date: 2009-09-22 Revised Date: 2012-02-29 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 034015 Citation Subset: IM |
Affiliation:
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University of Pennsylvania, Department of Physics, 209 South 33rd Street, Philadelphia, Pennsylvania 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Apnea / physiopathology Brain / blood supply*, metabolism, physiopathology Brain Injuries / metabolism, physiopathology* Disease Models, Animal Female Fluorescence Head Injuries, Closed / metabolism, physiopathology* Heart Arrest / physiopathology Hemoglobins / analysis Linear Models Optics and Photonics / methods* Oximetry Oxygen / analysis, blood Oxyhemoglobins / analysis Reproducibility of Results Spectroscopy, Near-Infrared / methods Spectrum Analysis / methods* Swine |
| Grant Support | |
ID/Acronym/Agency:
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ED-26979//PHS HHS; NR-0016/NR/NINR NIH HHS; R01 EB002109-15/EB/NIBIB NIH HHS; R01 HL077699-04/HL/NHLBI NIH HHS; R01 NS039679-07/NS/NINDS NIH HHS; R01 NS060653-04/NS/NINDS NIH HHS; R01-HL-077699/HL/NHLBI NIH HHS; R01-NS-39679/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins; 0/Oxyhemoglobins; 7782-44-7/Oxygen; 9008-02-0/deoxyhemoglobin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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