Document Detail

Diffuse myelitis after treatment of cerebral aspergillosis in an immune competent patient.
MedLine Citation:
PMID:  21874647     Owner:  NLM     Status:  MEDLINE    
Presentation of an unusual case of cerebral aspergillosis in an immune competent patient who was treated successfully but symptoms and signs of a demyelinating process following initial recovery has been occurred. A 29-year-old male with focal seizure. Brain MRI revealed small multiple hemispheric and dural lesions. An open biopsy was conducted. Histological evaluation revealed hyphe-like structure in the necrotic area, within vessel walls, and lumina, suggestive aspergillus fumigatus . Furthermore, brancheal hyphae in potassium hydrxide 15% and colonies on sabourud dextrose agar were observed. Based of the above findings the patient underwent anti fungal therapy. The patient recovered and continued a normal life however a follow up MRI was performed after 3 months from recovery. No significant abnormality was observed from the MRI procedure. One month later the patient developed signs and symptoms of spinal cord involvement which seemed to be the result of myelitis. A brain MR showed no abnormalities .Therefore it seemed reasonable to administer corticosteroid as a treatment for suspected active demyelinating process. During the above treatment, signs and symptoms of myelopathy disappeared and a whole spine MRI showed remarkable improvement.
Reza Mollahoseini; Mahdi Nikoobakht
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta medica Iranica     Volume:  49     ISSN:  1735-9694     ISO Abbreviation:  Acta Med Iran     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-29     Completed Date:  2011-12-23     Revised Date:  2012-01-10    
Medline Journal Info:
Nlm Unique ID:  14540050R     Medline TA:  Acta Med Iran     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  402-6     Citation Subset:  IM    
Department of Neurosurgery, Firoozgar Hospital, Tehran University of Medical Science, Tehran, Iran.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Antifungal Agents / therapeutic use*
Aspergillus fumigatus / isolation & purification*
Brain Diseases / diagnosis,  drug therapy*,  immunology,  microbiology
Magnetic Resonance Imaging
Myelitis / diagnosis,  drug therapy,  immunology*
Neuroaspergillosis / diagnosis,  drug therapy*,  immunology,  microbiology
Seizures / microbiology
Treatment Outcome
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antifungal Agents

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