Document Detail

Diffuse large B-cell lymphoma with lung involvement in a psoriatic arthritis patient treated with methotrexate.
MedLine Citation:
PMID:  20492818     Owner:  NLM     Status:  MEDLINE    
Non-Hodgkin lymphoma (NHL) occurs in the setting of methotrexate (MTX) therapy for rheumatoid arthritis. However, it has been very rarely reported in subjects with psoriatic arthritis treated with MTX. We report here a case of a 70-year-old woman with psoriatic arthritis who presented with bilateral lung infiltrates, pleural effusion, splenomegaly, and inguinal lymphadenopathy during treatment with MTX. The diagnosis of diffuse large B-cell lymphoma was made by analysis of the pleural fluid via thoracentesis and biopsy of an enlarged inguinal lymph node. Clinicians should consider the possibility of a NHL complicating psoriasis and with MTX therapy in order to prevent treatment delays.
Samer Homsi; Doru T Alexandrescu; Natasa Milojkovic; Wissam Abouzgheib; Khaled Bachour; Yamen Homsi; Constantin A Dasanu
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2010-05-15
Journal Detail:
Title:  Dermatology online journal     Volume:  16     ISSN:  1087-2108     ISO Abbreviation:  Dermatol. Online J.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-08-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610776     Medline TA:  Dermatol Online J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1     Citation Subset:  IM    
Pulmonary and Critical Care Medicine, St. Edwards Mercy Medical Center, Fort Smith, Arkansas, USA.
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MeSH Terms
Arthritis, Psoriatic / drug therapy*
Dermatologic Agents / adverse effects*
Lung Neoplasms / chemically induced*
Lymphoma, Large B-Cell, Diffuse / chemically induced*
Methotrexate / adverse effects*
Reg. No./Substance:
0/Dermatologic Agents; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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