Document Detail


Diffuse intracerebral calcification in a Beta-thalassaemia major patient with hypoparathyroidism: a case report.
MedLine Citation:
PMID:  21705988     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Beta-thalassemia major is a complex medical problem found worldwide. Endocrinopathies are some of the most frequent dysfunctions found in these patients. Iron overload in different organs is responsible for multiple endocrine complications particularly in the absence of adequate chelation therapy. One of the most prevalent endocrine complications of thalassemia major is hypoparathyroidism. It can cause cerebral calcifications in the basal ganglia but seldom outside of the extrapyramidal system. There are few studies about intracerebral calcification due to hypoparathyroidism in patients with thalassemia major. We report the case of a 14 year-old girl who came to our Center with the chief complaint of a generalized tonic-clonic seizure. The patient was known to have beta-thalassemia major since she was 9 months old. Computerized tomographic scan of the brain was done which showed diffuse intracranial calcifications in deep white matter, posterior fossa, basal ganglia and both thalami. Laboratory and neuroimaging assessments revealed the diagnosis of hypoparathyroidism. We strongly recommend periodic assessment and tight control of serum calcium level in all patients with betathalassemia major. Prompt treatment with oral calcium supplements and an active form of vitamin D can prevent hypoparathyroidism and its neurologic complications. Comprehensive evaluation and treatment of other endocrinopathies in accordance with hypoparathyroidism is suggested.
Authors:
Mojtaba Mahmoodi; Vincenzo De Sanctis; Mehran Karimi
Related Documents :
8270338 - Epidermodysplasia verruciformis in africans.
12492968 - Cutaneous findings associated with chronic natural killer cell lymphocytosis.
1932628 - Zinc, carotene, and retinol in melanoma and non-melanoma skin cancer.
21136698 - Elevated haptoglobin level of cerebrospinal fluid in guillain-barré syndrome revealed ...
6966908 - Serological abnormalities in juvenile chronic arthritis: a review of 46 cases.
443878 - Primary osteoathrosis of the hip and heberden's nodes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric endocrinology reviews : PER     Volume:  8 Suppl 2     ISSN:  1565-4753     ISO Abbreviation:  Pediatr Endocrinol Rev     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-06-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101202124     Medline TA:  Pediatr Endocrinol Rev     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  331-3     Citation Subset:  IM    
Affiliation:
Hematology Research Center, Nemazee Hospital Shiraz; University of Medical Sciences, Shiraz, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adrenal incidentaloma in thalassemia: a case report and literature review.
Next Document:  Generalized tonic-clonic seizures in a thalassemic patient with hypoparathyroidism and brain calcino...