Document Detail

Diffuse infantile haemangiomatosis: clinicopathological features and management problems in five fatal cases.
MedLine Citation:
PMID:  1843615     Owner:  NLM     Status:  MEDLINE    
The clinicopathological features of five fatal cases of diffuse haemangiomatosis presenting in neonatal life or early infancy are presented. The infants all had multiple skin haemangiomas as well as deep-seated lesions in many different tissues that caused protean clinical manifestations and management problems. Because the outlook may be improved by early diagnosis and application of new modes of treatment, any infant with multiple cutaneous haemangiomas should be closely assessed for possible visceral involvement. Development of hepatomegaly, high-output cardiac failure, unexplained anaemia or thrombocytopenia in these infants should immediately suggest disseminated disease. Early recognition with implementation of steroid and/or antiangiogenic therapy, embolization and/or surgery is essential to improve the chances of survival.
R W Byard; P E Burrows; T Izakawa; M M Silver
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of pediatrics     Volume:  150     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-06-20     Completed Date:  1991-06-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  224-7     Citation Subset:  IM    
Department of Pathology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
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MeSH Terms
Hemangioma* / pathology,  therapy
Hemangioma, Cavernous / pathology,  therapy
Infant, Newborn
Skin Neoplasms* / pathology,  therapy
Comment In:
Eur J Pediatr. 1992 May;151(5):389   [PMID:  1396900 ]

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