Document Detail

Diffuse follicle center lymphoma of the spine: a primary epidural lymphoma?
MedLine Citation:
PMID:  19788057     Owner:  NLM     Status:  MEDLINE    
A 72-year-old right-handed woman presented with a 6-month history of right thoracic wall discomfort. An MRI of the thoracic spine showed a small dumbbell-shaped mass centered within the right T7-8 foramen. The patient was asked to return to clinic for reevaluation to include a new MRI of the thoracic spine in 6 months. She did not comply with this recommendation and 1 year later, she presented with increasing difficulty ambulating and spastic paraparesis. A follow-up MRI of the thoracic spine now demonstrated significant interval growth of the mass with an extra-foraminal component extending into the thoracic cavity. She was taken to the operating room for resection of the epidural tumor. The pathology was consistent with diffuse follicle center lymphoma as cells were immunohistologically positive for CD20, CD 10, BCL-2 and BCL-6. Primary spinal follicle center lymphomas of the spine are rare with the current case being the first diffuse follicle center type reported in the literature.
F B Mesfin; D Drazin; S Berry; S Homan; T Nazeer; J W German
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neuropathology     Volume:  28     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2009-09-30     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
The Neurosciences Institute, Division of Neurosurgery, Albany Medical Center, New York 12208, USA.
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MeSH Terms
Antigens, CD20 / metabolism
DNA-Binding Proteins / metabolism
Epidural Neoplasms / metabolism,  pathology*,  surgery
Lymphoma / metabolism,  pathology*,  surgery
Magnetic Resonance Imaging
Movement Disorders / etiology
Neprilysin / metabolism
Paraparesis, Spastic / etiology
Proto-Oncogene Proteins c-bcl-2 / metabolism
Spinal Neoplasms / metabolism,  pathology*,  surgery
Thoracic Vertebrae
Reg. No./Substance:
0/Antigens, CD20; 0/BCL6 protein, human; 0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins c-bcl-2; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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