| Diffuse follicle center lymphoma of the spine: a primary epidural lymphoma? | |
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MedLine Citation:
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PMID: 19788057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 72-year-old right-handed woman presented with a 6-month history of right thoracic wall discomfort. An MRI of the thoracic spine showed a small dumbbell-shaped mass centered within the right T7-8 foramen. The patient was asked to return to clinic for reevaluation to include a new MRI of the thoracic spine in 6 months. She did not comply with this recommendation and 1 year later, she presented with increasing difficulty ambulating and spastic paraparesis. A follow-up MRI of the thoracic spine now demonstrated significant interval growth of the mass with an extra-foraminal component extending into the thoracic cavity. She was taken to the operating room for resection of the epidural tumor. The pathology was consistent with diffuse follicle center lymphoma as cells were immunohistologically positive for CD20, CD 10, BCL-2 and BCL-6. Primary spinal follicle center lymphomas of the spine are rare with the current case being the first diffuse follicle center type reported in the literature. |
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Authors:
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F B Mesfin; D Drazin; S Berry; S Homan; T Nazeer; J W German |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical neuropathology Volume: 28 ISSN: 0722-5091 ISO Abbreviation: Clin. Neuropathol. Publication Date: 2009 Sep-Oct |
Date Detail:
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Created Date: 2009-09-30 Completed Date: 2009-10-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8214420 Medline TA: Clin Neuropathol Country: Germany |
Other Details:
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Languages: eng Pagination: 395-9 Citation Subset: IM |
Affiliation:
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The Neurosciences Institute, Division of Neurosurgery, Albany Medical Center, New York 12208, USA. mesfinfb@mail.amc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antigens, CD20 / metabolism DNA-Binding Proteins / metabolism Epidural Neoplasms / metabolism, pathology*, surgery Female Humans Immunohistochemistry Lymphoma / metabolism, pathology*, surgery Magnetic Resonance Imaging Movement Disorders / etiology Neprilysin / metabolism Paraparesis, Spastic / etiology Proto-Oncogene Proteins c-bcl-2 / metabolism Spinal Neoplasms / metabolism, pathology*, surgery Thoracic Vertebrae |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD20; 0/BCL6 protein, human; 0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.24.11/Neprilysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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